NEJM This Week

Featuring articles on the cardiovascular safety of lorcaserin in obesity, extended thromboprophylaxis after hospitalization, diarrheal burden among African children, and Medicare spending in the MSSP; a review article on antibody-mediated rejection of solid-organ allografts; a case report of a woman with infertility; and Perspective articles on the FDA Amendments Act of 2007, on adolescents' use of "Pod Mod" e-cigarettes, on the CMS proposal to reform office-visit payments, and on doctoring while sick.

Featuring articles on tafamidis for transthyretin amyloid cardiomyopathy, fingolimod vs. interferon for pediatric MS, residual disease in myelodysplastic syndrome, BRCA2 and ovarian development, and prostate cancer and checkpoint inhibition; review articles on primary hyperparathyroidism and on aspirin-exacerbated respiratory disease; a case report of a man with epistaxis, pain and erythema of the forearm, and pancytopenia; and Perspective articles on the tobacco Master Settlement Agreement, on regulating drug prices, and to be guided by instinct.

Featuring articles on influenza treatment, rituximab plus lenalidomide in follicular lymphoma, coronary CT angiography and myocardial infarction, and quality of care after the removal of incentives; a review article on extracellular vesicles; a Clinical Problem-Solving describing something just below the surface; and Perspective articles on a new threat to immigrants' health, on the violence of uncertainty, on crossing borders, on protecting mothers and babies, and on voluntary euthanasia.

Featuring articles on emicizumab bleeding prophylaxis in hemophilia A; antimicrobial susceptibility in TB; the march to global eradication of poliomyelitis; small-molecule treatment of progressive MS; and bile, immunity, and hepatocellular carcinoma; a review article on Langerhans-cell histiocytosis; a case report of a boy with seizures; and Perspective articles on ending the use of an oral poliovirus vaccine, on mitigating the risks of Medicaid work requirements, on personalized hospital ratings, and on life lessons from Paul in the face of death.

Featuring articles on epinephrine in cardiac arrest, immunotherapy for melanoma brain metastases, tranexamic acid for preventing blood loss, carbetocin to prevent hemorrhage after vaginal birth, and talazoparib in BRCA-mutated breast cancers; a review article on Lynch syndrome-associated colorectal cancer; a case report of a man with fever, chills, myalgias, and rash; and Perspective articles on tickborne diseases, on the Republican war on Obamacare, on radical changes for reproductive health care, and on a remembrance of life before Roe v. Wade.

Featuring articles on alteplase for stroke with unknown onset; smoking cessation, weight, diabetes, and mortality; risk factors and cardiovascular outcomes in type 2 diabetes; ibalizumab for HIV-1 treatment; and biosensing internal bleeding; a review article on hypertrophic cardiomyopathy; a case report of a man with syncope; and Perspective articles on the parenteral opioid shortage, on fractional-dose yellow fever vaccination, and on lessons from an angry patient.

Featuring articles on labor induction vs. expectant management, cardiac screening of adolescent soccer players, vitamin D in pregnancy and lactation and infant growth, closed-loop insulin delivery in noncritical care, and active-shooter response at a health care facility; a review article on viral encephalitis; a case report of a man with acute renal failure and hematuria; and Perspective articles on reconciling federal and state marijuana policy, on opioid prescribing limits for acute pain, on a road map for sustaining healthy eating behavior, and on fighting burnout.

Featuring articles on nephrectomy in metastatic renal-cell carcinoma, copeptin and the diagnosis of diabetes insipidus, treatment of latent tuberculosis infection in adults, rifampin vs. isoniazid in children, and probing pain; a review article on an assay of circulating cell-free DNA in pregnancy; a Clinical Problem-Solving describing a headache of a diagnosis; and Perspective articles on accreditation of clinical research sites, on firearm injuries and violence prevention, on sociogenetic risks, and on deliberating death in the summer of 1968.

Featuring articles on prehospital plasma for patients at risk for shock, dengue vaccination, PD-1 blockade in advanced squamous skin cancer, an oral kallikrein inhibitor for hereditary angioedema, and surgical gatekeeping; a review article on keratinocyte carcinomas; a case report of a man with episodes of confusion and hypoglycemia; and Perspective articles on trolleyology and the dengue vaccine dilemma, on the payment-reform wild card, on saving thyroids, and on a cup of coffee.

Featuring articles on dual antiplatelet treatment after minor stroke, effects of L-glutamine on sickle cell-related pain, procalcitonin in the treatment of acute respiratory illness, five-year outcomes with FFR-guided PCI, Medicare's bundled payments for medical conditions, and clonal hematopoiesis and hematologic cancer; a review article on psychosis; a case report of a man with leg weakness, recurrent falls, and anemia; and Perspective articles on the FDA and the next wave of drug abuse, on turning the tables, on Twitter tailwinds, and on the inevitable math behind entitlement reform.

Featuring articles on treating hereditary transthyretin amyloidosis, platelet counts during pregnancy, tecovirimat for smallpox, cabozantinib in hepatocellular carcinoma, and epigenetic control of interleukin-9 levels in asthma; a review article on chimeric antigen receptor T cells; a Clinical Problem-Solving article describing a sickening tale; and Perspective articles on improving addiction care and on whether you would forgive the doctor for saving you.

Featuring articles on enzalutamide in biochemical relapse of prostate cancer, dupilumab for moderate-to-severe asthma, and the safety of long-acting B2-agonists in asthma; a review article on preventing gastrointestinal bleeding in the hospital; a case report of a man with fever, arthralgias, and testicular pain; and Perspective articles on personhood and the three branches of government, on making neighborhood-disadvantage metrics accessible, on transitioning to clinical metastases, and on inhaled corticosteroids and LABAs.

Featuring articles on a family intervention led by nurses in the ICU, sodium thiosulfate and cisplatin-induced hearing loss, ivosidenib in IDH1-mutated acute myeloid leukemia, ibrutinib plus rituximab in Waldenstrom's macroglobulinemia, informed consent and the role of the treating physician, and epithelial cells and the alveolus; a review article on subclinical hyperthyroidism; a case report of a girl with acute kidney injury; and Perspective articles on doing Ebola research during an emergency, on why the VA needs more competition, on the growing ranks of advanced practice clinicians, and on the Graduate Nurse Education Demonstration.

Featuring articles on restrictive versus liberal fluid therapy, fluid administration for pediatric diabetic ketoacidosis, atezolizumab plus chemotherapy in lung cancer, approaches to smoking cessation, and social media and advancement of women physicians; a review article on breast cancer in men; a case report of a woman with hypertension, fatigue, and altered mental status; and Perspective articles on recognizing blind spots, on lost Taussigs, and on the end of nuclear weapons or the end of us.

Featuring articles a single-inhaler glucocorticoid-B-agonist in mild asthma, cannabidiol in the Lennox-Gastaut syndrome, cerliponase alfa for CLN2 disease, and canakinumab in autoimmune inflammatory fevers; a review article on supply and quality of deceased-donor organs; a case report of a woman with nausea, vomiting, and confusion; and Perspective articles on addressing generic-drug market failures, on HIV population surveys, and on leadership development in medicine.