Summary: Featuring articles on emicizumab bleeding prophylaxis in hemophilia A; antimicrobial susceptibility in TB; the march to global eradication of poliomyelitis; small-molecule treatment of progressive MS; and bile, immunity, and hepatocellular carcinoma; a review article on Langerhans-cell histiocytosis; a case report of a boy with seizures; and Perspective articles on ending the use of an oral poliovirus vaccine, on mitigating the risks of Medicaid work requirements, on personalized hospital ratings, and on life lessons from Paul in the face of death.
