NEJM This Week

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

We discuss the latest in medical research and ideas.

Featuring articles on alirocumab treatment after acute coronary syndrome, a checkpoint inhibitor in advanced breast cancer, the diagnosis of ADHD and age at entry into kindergarten, drilling down on diagnostic method, and a Medicare Advantage checkup; a review article on iron chelation; a case report of a woman with vision loss; and Perspective articles on neonatal organ donation, on the Sentinel Initiative, and on trauma-informed care.

Featuring articles on oral peanut desensitization, probiotics for acute gastroenteritis in children, brigatinib in ALK-positive lung cancer, chemoimmunotherapy for squamous lung cancer, and a tug of war between bacterium and host; a review article on the central role of PI3K in cell signaling; a case report of a man with an incidentally discovered renal mass; and Perspective articles on new tools in the Ebola arsenal, on going beyond evidence-based medicine, on fulfilling states' duty to evaluate Medicaid waivers, and on Doctor Sahib.

Featuring articles on surgery for early cervical cancer, preventing tuberculosis-associated IRIS, palbociclib plus fulvestrant in advanced breast cancer, and case studies in social medicine; a review article on lymphedema after breast cancer treatment; a case report of a woman with back pain and a remote history of breast cancer; and Perspective articles on medicalization and demedicalization, on looking beyond mortality in transplantation outcomes, and on reimagining development assistance for health.

Featuring articles on treatment for lymphatic filariasis, combination therapy for relapsed myeloma, increasing calorie delivery in the critically ill, zoliflodacin for gonorrhea, daratumumab for transplant-related pure red-cell aplasia, and suppression of casein kinase 1 alpha in AML; a review article on ethical issues in the neonatal ICU; a case report of a woman with paresthesia and weakness of the foot and abdominal wall; and Perspective articles on getting rid of stupid stuff, on immunotherapy combinations in multiple myeloma, on gonorrhea, and on terra nova.

Featuring articles on PCI strategies in cardiogenic shock, macrophage checkpoint blockade with anti-CD47 in lymphoma, sildenafil for symptoms of idiopathic pulmonary fibrosis, health care-associated infections in U.S. hospitals, and Lassa fever in Nigeria; a review article on emerging roles of cell-free tumor DNA in oncology; a Clinical Problem-Solving describing a complex deposit; and Perspective articles on what we can do about maternal mortality, on postpartum care in the United States, on health regulation for the digital age, and on becoming a caregiver.

Featuring articles on triple combination therapies for cystic fibrosis, a phase 2b trial of a TB vaccine, and fetal hemoglobin and the hemoglobinopathies; review articles on diverticulitis and on aplastic anemia; a case report of a man with confusion, fever, malaise, and weight loss; and Perspective articles on ending sexual harassment in academic medicine, on payment and delivery-system reform, and on learning empathy from a '97 Camry.

Featuring articles on aspirin and on n−3 fatty acids in diabetes mellitus; a review article on addiction as a disease or a consequence of learning; a case report of a pregnant woman with newly diagnosed adenocarcinoma; and Perspective articles on the Supreme Court's crisis pregnancy center case, on abortion "reversal", on extensively drug-resistant typhoid, and on "transparency" as a mask.

Featuring articles on assessing drug susceptibility in tuberculosis, genetic classification of myeloproliferative neoplasms, renal-replacement therapy in acute kidney injury, treatment of PML with BK virus-specific T cells, and histone methylation in neuroblastoma; a review article on ontologies, phenotypes, and big data; a case report of a man with a self-inflicted gunshot wound; and Perspective articles on the next phase of human gene-therapy oversight, on national coverage analysis of CAR-T therapies, on "precision" public health, and on a seat at the table.

Featuring articles on BMI acceleration in early childhood and obesity risk, a trial of an oral TYK2 inhibitor in psoriasis, Candida auris in a neurosciences ICU, and rivaroxaban in patients with heart failure; review articles on acne vulgaris and on clinical next-generation sequencing; a Clinical Problem-Solving describing a tricky diagnosis; and Perspective articles on being PrEPared, on dialysis-facility joint-venture ownership, on the physician as double agent, and on the name of the dog.

Featuring articles on a wearable cardioverter-defibrillator after myocardial infarction, superwarfarin contamination of cannabinoid products, restrictive or liberal transfusion for cardiac surgery, persistence of Zika virus in body fluids, recovery of over-ground walking after spinal injury, and RNA biology and parity at the bench; a review article on alcohol use in patients with chronic liver disease; a case report of a woman with chronic abdominal pain; and Perspective articles on how to stop mass shootings, on mental health services for medical students, on outbreaks in a rapidly changing Central Africa, and on murmurs of politics and economics.