NEJM This Week

Featuring articles on air pollution and mortality in the Medicare population, electrical direct current vs. escitalopram for depression, levothyroxine in older adults with subclinical hypothyroidism, and antibiotics for skin abscess; review articles on subclinical hypothyroidism and on the irritable bowel syndrome; a case report of a man with weight loss, confusion, and skin lesions; and Perspective articles on prospects for health care reform in the U.S. Senate, on FDA approval of valbenazine for tardive dyskinesia, on machine learning and prediction in medicine, and on decision aids and elective joint replacement.

Featuring articles on nivolumab in untreated lung cancer, a cell-culture influenza vaccine, lying flat versus sitting up after acute stroke, the glucocorticoid-sparing effect of benralizumab in asthma, and understanding early events in breast cancer; a review article on post-traumatic stress disorder; a case report of a woman with leg numbness and weakness; and Perspective articles on the AHCA, on the first hundred days for health care, on effective legislative advocacy, and on incarceration and health.

Featuring articles on bioresorbable vascular scaffolds in routine PCI, treatment for Talaromyces marneffei, buprenorphine in the neonatal abstinence syndrome, single-nephron GFR in healthy adults, changes in quality with Hospital Value-Based Purchasing, and a tale of two doctors; a review article on diabetic foot ulcers and their recurrence; a case report of a girl with difficulty eating after a choking incident; and Perspective articles on the waiting game, on state sepsis mandates, on separating families at the border, and on the morning report.

Featuring articles on cannabidiol for seizures in the Dravet syndrome, levosimendan after cardiac surgery, oil or water contrast for hysterosalpingography, nicotinamide and glaucoma, and medical assistance in dying; a review article on acute myocardial infarction; a case report of a woman with urinary incontinence; and Perspective articles on accelerated approval and expensive drugs, on emerging from EHR purgatory, and on sharing clinical and genomic data on cancer.

Featuring articles on KIT inhibition by imatinib in severe asthma, treating eosinophilic granulomatosis with polyangiitis, evacetrapib in high-risk vascular disease, exercise training in dieting obese older adults, and ularitide in acute heart failure; a review article on the physiological effect of chronic hypoxia; a case report of a woman with skin lesions after travel abroad; and Perspective articles on physicians, firearms, and free speech; on the the committed perspective; on creating a real-world information economy; and on a letter to a young female physician.

Featuring articles on instantaneous wave-free ratio vs. fractional flow reserve, not-so-benign endometriosis, use of the NHLBI data repository, and testing Zika virus vaccines; a review article on cerebral arteriovenous malformations; a case report of a man with swelling of the calf and a rash; and Perspective articles on the future of transgender coverage, on big insurance mergers, on medical liability, and on CABG at 50 (or 107?).

Featuring articles on evolocumab and cardiovascular outcomes, tofacitinib for ulcerative colitis, bystander efforts in out-of-hospital cardiac arrest, and teprotumumab for thyroid-associated ophthalmopathy; review articles on partnerships among researchers, patient groups, and industry and on acute kidney injury in patients with cancer; a Clinical Problem-Solving article on going back to the history; and Perspective articles on why Trump’s NIH funding cuts would be a disaster, on resident duty hours, on how the FDA saved taxpayers billions, and on health insurance and emergency department use.

Featuring articles on BAFF overexpression and autoimmunity in Sardinia, dabigatran versus warfarin for ablation in atrial fibrillation, adalimumab plus methotrexate for uveitis associated with juvenile idiopathic arthritis, GPIHBP1 autoantibodies and chylomicronemia, data authorship as an incentive to data sharing, and stabilizing the mixed lineage leukemia protein; a review article on the physical abuse of children; a case report of a man with hearing loss, seizures, and cognitive decline; and Perspective articles on preventive medicine for the planet and its peoples, resisting the suppression of science, a precision delivery initiative for precision medicine, and board review and the middle-aged doctor.

Featuring articles on screening for retinopathy in type 1 diabetes, variability in lipid reduction with bococizumab, cardiovascular outcomes with bococizumab, eltrombopag and immunosuppression for aplastic anemia, and risankizumab vs. ustekinumab for plaque psoriasis; a review article on sickle cell disease; a case report of a man with nephropathy; and Perspective articles on the Republicans' health care reform muddle, on a citizen's pathway gone astray, on addressing the opioid epidemic, and on reevaluating eligibility criteria.

Featuring articles on mortality and cardiovascular disease in diabetes, incidence trends of diabetes among youths, inclisiran in patients with elevated LDL cholesterol, emergency care delays and mortality during marathons, a net finding in fibrosis, and who decides when a patient can't; a review article on Cushing's syndrome; a case report of a woman with leg swelling, back pain, and hydronephrosis; and Perspective articles on yellow fever, on the perils of Trumping science in global health, on ensuring access to injectable generic drugs, and on lessons from Standing Rock.

Featuring articles on RVD therapy plus stem-cell transplantation for myeloma, surgical versus transcatheter aortic-valve replacement, body-weight fluctuations and coronary disease outcomes, two-year outcomes of endovascular thrombectomy for stroke, and conscientious objection in health care; review articles on an FDA viewpoint on medical-device clinical trials and on spinal cord compression; a Clinical Problem-Solving article on a bare-bones approach; and Perspective articles on providing rural health care.

Featuring articles on extended anticoagulation in venous thromboembolism, quadrivalent HPV vaccination and pregnancy outcomes, fractional flow reserve-guided multivessel angioplasty in myocardial infarction, DHA and bronchopulmonary dysplasia in preterm infants, prostate cancer screening, and throwing the genome at HIV-1; a review article on maternal immunization; a case report of a boy with gastrointestinal bleeding and abdominal pain; and Perspective articles on Trump's executive order on health care, on calibrating real-world data, on modifying SNAP to promote population health, and on motorcycle-helmet laws and public health.

Featuring articles on pregabalin for sciatic pain, an oral rotavirus vaccine in Niger, prevention of hereditary angioedema attacks, blockade of IL-12 and IL-23 in LAD1, the advantages of a truly open-access data-sharing model, and the Trump Administration and the environment; a review article on benzodiazepine dependence; a case report of a woman with nausea, confusion, and hyponatremia; and Perspective articles on Kathryn, a fourth-year medical student who ended her life last August; on breaking the stigma; on adopting innovations in care delivery; and on patient inducements.

Featuring articles on pembrolizumab for advanced urothelial cancer, temozolomide plus radiotherapy in glioblastoma, induced pluripotent stem-cell-based transplantation, vision loss and intravitreal "stem-cell" injection, lessons from Oregon about end-of-life care, and induced rejuvenation; a review article on acute lower gastrointestinal bleeding; a case report of a Zimbabwean man with a severe headache; and Perspective articles on per capita caps in Medicaid, on clarifying stem-cell therapy's benefits and risks, on improving hospital incentives with better cost data, and on another senseless death.

Featuring articles on imatinib in chronic myeloid leukemia, chimpanzee adenovirus vector Ebola vaccine, post-babesiosis hemolytic anemia, access during the first 2 years of Medicaid expansions, and implementing effective cancer-prevention strategies; a review article on psoriatic arthritis; a case report of a man with confusion and recurrent epistaxis; and Perspective articles on anesthesia and developing brains, on success and failure in the insurance exchanges, on children at risk for serious mental illness, and on getting real about health care costs.