Gut podcast show

Gut podcast

Summary: From June 2023, all our podcasts will move to https://gutbmj.podbean.com. You can continue with your subscription on your favourite podcast App. Gut is a leading international journal in gastroenterology and hepatology. It has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage of all areas in gastroenterology. Regular features include articles by leading authorities, reports on the latest treatments for diseases, reviews and commentaries. Subscribers to Gut also receive Frontline Gastroenterology (FG). The Gut Podcast discusses highlights from its issues monthly. Please subscribe in all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify. * The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

Podcasts:

 Mesalazine and thymoquinone attenuate intestinal tumour development in mice | File Type: audio/mpeg | Duration: 19:06

In this podcast Dr Mairi McLean talks to Dr Christoph Gasche about his editors choice paper "Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2loxP/loxP Villin-Cre mice." Full paper >> http://gut.bmj.com/content/64/12/1905.full

 Effects of bowel cleansing on the intestinal microbiota | File Type: audio/mpeg | Duration: 11:11

In this podcast Dr Mairi McLean talks to Dr Joanna Jalanka about her recently published article in Gut entitled "Effects of bowel cleansing on the intestinal microbiota". They discuss what was already known in the field and what has since been discovered, and how long these effects last and how the microbiota were measured.

 Effects of bowel cleansing on the intestinal microbiota | File Type: audio/mpeg | Duration: 11:11

In this podcast Dr Mairi McLean talks to Dr Joanna Jalanka about her recently published article in Gut entitled "Effects of bowel cleansing on the intestinal microbiota". They discuss what was already known in the field and what has since been discovered, and how long these effects last and how the microbiota were measured.

 Development of an enhanced human gastrointestinal epithelial culture system | File Type: audio/mpeg | Duration: 22:10

Mairi McLean talks to Thaddeus S Stappenbeck, Department of Pathology and Immunology, Washington University School of Medicine, about his paper: Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Read the full paper: http://goo.gl/xeWDHz

 Development of an enhanced human gastrointestinal epithelial culture system | File Type: audio/mpeg | Duration: 22:10

Mairi McLean talks to Thaddeus S Stappenbeck, Department of Pathology and Immunology, Washington University School of Medicine, about his paper: Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Read the full paper: http://goo.gl/xeWDHz

 Helicobacter pylori targets cancer-associated apical-junctional constituents | File Type: audio/mpeg | Duration: 14:09

Helicobacter pylori strains that express the a protein that increases the risk of gastric cancer. However, the precise mechanisms through which the cancer risk is heightened have not been fully investigated and understood. In this podcast Dr Mairi McLean talks to Dr Lydia Wroblewski from the Vanderbilt University School of Medicine about the study her group conducted to define mechanisms through which H. pylori modulates expression of the cancer-associated tight junction protein claudin-7. To read the full paper please visit http://gut.bmj.com/content/64/5/720.full

 Helicobacter pylori targets cancer-associated apical-junctional constituents | File Type: audio/mpeg | Duration: 14:09

Helicobacter pylori strains that express the a protein that increases the risk of gastric cancer. However, the precise mechanisms through which the cancer risk is heightened have not been fully investigated and understood. In this podcast Dr Mairi McLean talks to Dr Lydia Wroblewski from the Vanderbilt University School of Medicine about the study her group conducted to define mechanisms through which H. pylori modulates expression of the cancer-associated tight junction protein claudin-7. To read the full paper please visit http://gut.bmj.com/content/64/5/720.full

 Diagnosis and management of acute kidney injury in patients with cirrhosis | File Type: audio/mpeg | Duration: 13:16

Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in 1996 and have been refined in subsequent years. More recently the International Club of Ascites (ICA)redefined the criteria to reach a new definition of acute kidney injury (AKI) in patients with cirrhosis. Dr Mairi McLean speaks to lead author Professor Paolo Angeli from the University of Padova about the scientific evidence supporting the new approach to the diagnosis and treatment of acute kidney injury.Read the full article >> http://gut.bmj.com/content/64/4/531.full

 Diagnosis and management of acute kidney injury in patients with cirrhosis | File Type: audio/mpeg | Duration: 13:16

Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in 1996 and have been refined in subsequent years. More recently the International Club of Ascites (ICA)redefined the criteria to reach a new definition of acute kidney injury (AKI) in patients with cirrhosis. Dr Mairi McLean speaks to lead author Professor Paolo Angeli from the University of Padova about the scientific evidence supporting the new approach to the diagnosis and treatment of acute kidney injury.Read the full article >> http://gut.bmj.com/content/64/4/531.full

 Demonstration of the usefulness of epigenetic cancer risk prediction | File Type: audio/mpeg | Duration: 16:11

Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. Dr Mairi McLean speaks to Dr Toshikazu Ushijima about his study investigating these defects and the association with gastric cancer.

 Demonstration of the usefulness of epigenetic cancer risk prediction | File Type: audio/mpeg | Duration: 16:11

Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. Dr Mairi McLean speaks to Dr Toshikazu Ushijima about his study investigating these defects and the association with gastric cancer.

 XIAP variants in male Crohn's disease | File Type: audio/mpeg | Duration: 27:34

The genetic basis of inflammatory bowel disease (IBD) is incompletely understood, and the aim of a recent study in Gut was to identify rare genetic variants involved in the pathogenesis of IBD. Mairi McLean speaks to authors Sebastian Zeissig, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, and Andre Franke, Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, to hear what they found. Read the full paper: http://gut.bmj.com/content/64/1/66.full

 XIAP variants in male Crohn's disease | File Type: audio/mpeg | Duration: 27:34

The genetic basis of inflammatory bowel disease (IBD) is incompletely understood, and the aim of a recent study in Gut was to identify rare genetic variants involved in the pathogenesis of IBD. Mairi McLean speaks to authors Sebastian Zeissig, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, and Andre Franke, Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, to hear what they found. Read the full paper: http://gut.bmj.com/content/64/1/66.full

 Cell lineage distribution atlas reveals heterogeneous gland populations in the gastric antrum | File Type: audio/mpeg | Duration: 14:26

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. Now a paper in Gut has examined in detail the distribution of the full range of cell lineages within the human stomach. Mairi McLean talks to authors James Goldenring, Eunyoung Choi and Joseph Roland, all Vanderbilt University School of Medicine, Nashville, Tennessee. Read the full paper: http://gut.bmj.com/content/63/11/1711.full

 Cell lineage distribution atlas reveals heterogeneous gland populations in the gastric antrum | File Type: audio/mpeg | Duration: 14:26

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. Now a paper in Gut has examined in detail the distribution of the full range of cell lineages within the human stomach. Mairi McLean talks to authors James Goldenring, Eunyoung Choi and Joseph Roland, all Vanderbilt University School of Medicine, Nashville, Tennessee. Read the full paper: http://gut.bmj.com/content/63/11/1711.full

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