Gut podcast

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Delzenne, President of the Louvain Drug Research Institute, at the UCLouvain, Brussels, Belgium. The podcast is focused on "Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients" published in paper copy in Gut in November 2020, and online at: https://gut.bmj.com/content/69/11/1975

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Dr Rima Chakaroun who is a Clinician Scientist, Resident physician at the University Hospital in Leipzig, Germany, specialising in Endocrinology and Metabolic disease and a postdoctoral researcher and clinical investigator working on microbiome signatures in obesity in gut and beyond. The podcast is focused on "Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes" published in paper copy in Gut in October 2020. https://gut.bmj.com/content/69/10/1796

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Dr Melina Arnold from the Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. The podcast is focussed on "Global burden of oesophageal and gastric cancer by histology and subsite in 2018" published in paper copy in Gut in September 2020 https://gut.bmj.com/content/69/9/1564

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Silvia Sookoian, who is Head of the Department of Clinical & Molecular Hepatology and Vice-Chair of Institute of Medical Research, at the Institute of Medical Research, Strategic Alliance between the National Scientific and Technical Research Council (CONICET)and the School of Medicine, University of Buenos Aires, Argentina; and Principal Investigator of the National Scientific and Technical Research Council. The podcast is focussed on "Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease" published in paper copy in Gut in August 2020. Link to the article: https://gut.bmj.com/content/69/8/1483

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Madgy El-Salhy, who is a Professor of Gastroenterology at Bergen University and Consultant Gastroenterologist at Stord Hospital, Norway, on the paper ‘Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study’ published in paper copy in Gut in May 2020 - https://gut.bmj.com/content/69/5/859

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Inga Peter, who is a Professor in the Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, on "Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice" published in paper copy in Gut in January 2020. Link to the paper: https://gut.bmj.com/content/69/1/42

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Paul O'Toole; who is Professor of Microbial Genomics, Head of School of Microbiology and Principal Investigator in APC Microbiome Ireland, an SFI funded centre at University College Cork, Ireland, on "Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across 5 European countries" published in paper copy in Gut in July 2020 https://gut.bmj.com/content/69/7/1218

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Jacques Bergman who is Professor of Gastrointestinal Endoscopy at the Amsterdam University Medical Center, Amsterdam on "Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study" published in paper copy in Gut in February 2020. Accessible online here: https://gut.bmj.com/content/69/2/295

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Cathryn Edwards, BSG President and Consultant Gastroenterologist at Torbay Hospital, Devon and Dr Nick Kennedy, Consultant Gastroenterologist, Royal Devon and Exeter NHS Foundation Trust on the British Society of Gastroenterology response to the coronavirus pandemic and on the guidance produced by a team of UK IBD Specialists entitled ‘BSG guidance for management of IBD during the COVID-19 pandemic’ to be published in paper copy in Gut in June 2020. Paper link is: http://dx.doi.org/10.1136/gutjnl-2020-321244 Acknowledgements - BSG Risk stratification Grid for IBD patients on Immunosuppression - huge thanks go to: - Prof Charlie Lees, BSG Clinical Research Group (CRG) Chair and Lead of the UK IBD COVID-19 working group. Dr Ian Arnott BSG IBD Section Lead. Dr Chris Lamb, Dr Barney Hawthorne, BSG Guidelines Development Group (GDG) 2019, Dr Gareth Jones and Dr Nick Kennedy (IBD GDG and CRG) and 70+ clinical colleagues who contributed to the collaborative discussions through the COVID -19 working group - The BSG, in particular Dr Cathryn Edwards, the BSG Executive team and BSG Staff - The IBD Registry Group: Dr Stuart Bloom and Liz Dobson and AIMES who delivered the technical aspects of the IBD Registry web tool - The Crohn's & Colitis UK team particularly Rukshana Kapasi BSPGHAN, particularly Prof Richard Russell, Dr Richard Hansen BSPGHAN President Sue Protheroe and Prof Mark Beattie, Editor of Frontline Gastroenterology - Donal Donoghue Registrar RCP London and Medical Specialty Colleagues The many patients whose feedback helped improve the IBD Registry COVID-19 tool and the BSG guidance - The RCN

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Ms Rebecca Siegel, Scientific Director of Surveillance Research at the American Cancer Society. Ms Rebecca Siegel is first author on the paper 'Global patterns and trends in colorectal cancer incidence in young adults' published in Gut in December 2019. Read the article - https://gut.bmj.com/content/68/12/2179

Dr Christopher Lamb, Clinical Intermediate Fellow at Newcastle University and Honorary Consultant in Gastroenterology at the Newcastle upon Tyne Hospitals NHS Foundation Trust discusses the BSG guidelines on the management of inflammatory bowel disease in adults with Associate Editor of GUT Dr Philip Smith. Read the article: https://gut.bmj.com/content/68/Suppl_3/s1

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. The guideline discussed in this podcast is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Marco del Chiaro, from The European Study Group on Cystic Tumours of the Pancreas. And read the details of the guidelines on the Gut website: https://gut.bmj.com/content/67/5/789.

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. The guideline discussed in this podcast is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Marco del Chiaro, from The European Study Group on Cystic Tumours of the Pancreas. And read the details of the guidelines on the Gut website: https://gut.bmj.com/content/67/5/789.

Clostridium difficile (C. difficile, C. diff or CDI) is a bacterium associated with the intake of antibiotics which causes diarrhoea. It is easily spread to others, both in hospital and a household environments. C. Diff infections are generally treated with antibiotics. Recurrent infection is successfully treated with faecal microbiota transplantation (FMT), however the underlying mechanism of action is not well defined. This study identified a key role of the virome within the transferred stool on treatment responses. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Siew Ng (The Chinese University of Hong Kong, China), who's the leading author of the Open Access paper “Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome”, included in the April 2018’s Gut issue (gut.bmj.com/content/67/4/634).

Clostridium difficile (C. difficile, C. diff or CDI) is a bacterium associated with the intake of antibiotics which causes diarrhoea. It is easily spread to others, both in hospital and a household environments. C. Diff infections are generally treated with antibiotics. Recurrent infection is successfully treated with faecal microbiota transplantation (FMT), however the underlying mechanism of action is not well defined. This study identified a key role of the virome within the transferred stool on treatment responses. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Siew Ng (The Chinese University of Hong Kong, China), who's the leading author of the Open Access paper “Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome”, included in the April 2018’s Gut issue (gut.bmj.com/content/67/4/634).