Author in the Room: Use of Gastric Acid-Suppressive Agents and the Risk of Community-Acquired Clostridium difficile-Associated Disease

Summary: This week: Recent reports suggest an increasing occurrence and severity of Clostridium difficile associated disease. The authors found that the use of acid-suppressive therapy, particularly proton pump inhibitors, is associated with an increased risk of community-acquired C difficile and state that the unexpected increase in risk with nonsteroidal anti-inflammatory drug use should be investigated further.