JBC News Podcast: Prion-mediated toxicity of Aβ oligomers: JBC’s best Neurobiology article of 2013

Summary: Feb 24 2014 — In this the second in our four-part podcast series on the best articles of 2013 in The Journal of Biological Chemistry we hear a conversation between Associate Editor Paul Fraser a professor in the Department of Medical Biophysics at the University of Toronto and Nigel Hooper from the Faculty of Biological Sciences at the University of Leeds in the United Kingdom Dr Hooper is the author of JBC’s Best Article of 2013 in the category of Neurobiology It is titled “Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1,” and it was published in March The paper focuses attention on how remodeling amyloid-β oligomers and disrupting the prion LRP1 raft interaction can provide therapeutic targets for Alzheimer disease Drs Fraser and Hooper talk about the progression of this work and where the research may lead