ASBMB AudioPhiles show

ASBMB AudioPhiles

Summary: ASBMB AudioPhiles is a monthly 'best of' summary which features research highlights from ASBMB journals. Our objective for this series of podcasts is to spotlight articles published in the Journal of Biological Chemistry, as well as other news of interest to biochemists and JBC readers. These include announcements, highlights of JBC Papers of the Week, JBC Classics, JBC Reflections, and JBC Mini Reviews. In the future, we will also be highlighting articles from the Journal of Lipid Research and Molecular and Cellular Proteomics, as well as items of editorial interest such as NIH funding and interviews with prominent biochemists.

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  • Artist: ASBMB
  • Copyright: The American Society for Biochemistry and Molecular Biology

Podcasts:

 Biomedical Research Funding | File Type: audio/mpeg | Duration: 30:00

Public Affairs Director Benjamin Corb joined SiriusXM's Stand Up with Pete Dominick on Thursday August 28th to discuss the state of biomedical research funding juxtaposed against the widely popular ALS Association Ice Bucket Challenge.  During the interview with host and CNN contributor Pete Dominick Ben discussed how we need more research funding not just for ALS but for basic biomedical research to provide breakthroughs in many diseases.  Listen as they discuss the funding raising campaign's success the way biomedical research is supported through the National Institutes of Health and how tax dollars do more than donations to battle disease.  Runtime approximately 30 minutes

 JBC News Podcast: α-synuclein, living cells and Parkinson’s disease: JBC’s best Cell Biology article of 2013 | File Type: audio/mpeg | Duration: 23:31

March 10 2014 — In the last of our four-part podcast series on the best articles of 2013 in the The Journal of Biological Chemistry we hear about the debate surrounding α-synuclein which plays a critical role in Parkinson’s disease Is it an unfolded monomer? Is it a helically-folded tetramer? Paul Fraser a professor of medical biophysics at the University of Toronto and a JBC associate editor speaks with Dennis Selkoe a professor of neurological diseases at Harvard Institutes of Medicine and Ulf Dettmer a research fellow in neurology also at Harvard Selkoe and Dettmer are co-authors of JBC’s best article of 2013 in the Affinity category of Cell Biology It is titled “In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells,” and it was published in March The paper details a new method for cross-linking α-synuclein in living cells that reveals a form consistent with a tetramer In this conversation we hear about the prior research leading to this article and what to look forward to as the debate continues

 JBC News Podcast: Key interactions at the HER2-HER3 kinase dimer interface: JBC’s best Signal Transduction article of 2013 | File Type: audio/mpeg | Duration: 15:08

March 3 2014 — In Part Three of our series of the best articles of 2013 in the The Journal of Biological Chemistry we hear a conversation between Alex Toker a professor in the Department of Pathology at Beth Israel Deaconess Medical Center and Ron Bose a medical oncologist and assistant professor in the Division of Biological and Biomedical Sciences at Washington University in St Louis Bose is the corresponding author of the paper “ Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface.” This paper was named the JBC’s Best Article of 2013 in the category of Signal Transduction The paper provides the first structural characterization of HER2-HER3 heterodimers which are part of the receptor family that is used in the development of targeted cancer therapies Here Bose talks about his more than 10 years of research in the study of tyrosine kinases He also talks about where the research is going the development of innovation where mass spectrometry is limited in the study of protein complexes that can’t be crystalized and the power of interdisciplinary studies for graduate students in science

 JBC News Podcast: Prion-mediated toxicity of Aβ oligomers: JBC’s best Neurobiology article of 2013 | File Type: audio/mpeg | Duration: 21:07

Feb 24 2014 — In this the second in our four-part podcast series on the best articles of 2013 in The Journal of Biological Chemistry we hear a conversation between Associate Editor Paul Fraser a professor in the Department of Medical Biophysics at the University of Toronto and Nigel Hooper from the Faculty of Biological Sciences at the University of Leeds in the United Kingdom Dr Hooper is the author of JBC’s Best Article of 2013 in the category of Neurobiology It is titled “Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1,” and it was published in March The paper focuses attention on how remodeling amyloid-β oligomers and disrupting the prion LRP1 raft interaction can provide therapeutic targets for Alzheimer disease Drs Fraser and Hooper talk about the progression of this work and where the research may lead

 JBC News Podcast: The N-terminal lobe regulating Argonaute slicer activity: JBC’s best RNA article of 2013 | File Type: audio/mpeg | Duration: 10:16

Feb 17 2014 — This podcast is the first in a four-part series on the article named the best of 2013 in The Journal of Biological Chemistry The Journal’s editors reviewed the more than 4,000 articles published throughout the year and named 22 among the best one article for each of the Journal’s Affinity categories An affinity category corresponds to a section of the Journal’s table of contents In our first podcast we talk briefly with Rachel Green a professor in the Department of Molecular Biology and Genetics at Johns Hopkins University School of Medicine She is the corresponding author of JBC’s Best Article of the Year in the category of RNA The article is titled “Regulation of Argonaute Slicer Activity by Guide RNA 3′ End Interactions with the N-terminal Lobe,” and it was published in March When asked about the paper’s significance JBC’s editor-in-chief Martha Fedor pointed out that RNA interference and microRNA pathways for gene silencing differ their effects on target RNAs and in the structures of the guide RNAs such as siRNAs and microRNAs that initiate each pathway She said this article provides important insight into how recognition of siRNA and microRNA structures by Argonaute proteins influences downstream effects on target RNAs Dr Green talked about her work the way this article came about and the direction she sees this research moving

 ASBMB Today podcast: September career symposium at University of Missouri | File Type: audio/mpeg | Duration: 04:47

On Sept 21 ASBMB sponsored a career symposium at the University of Missouri one of four career events sponsored by the society in 2013 ASBMB’s Kierra Craig gives us a report.

 JBC Podcast: Aminoacylating urzymes and the RNA world hypothesis -- an interview with Charles Carter of the University of North Carolina | File Type: audio/mpeg | Duration: 11:41

Sept 16 2013 — In this podcast we hear an interview with Charles Carter at the University of North Carolina who talks about his JBC Paper of the Week Aminoacylating Urzymes Challenge the RNA World Hypothesis The paper delves into how these peptide molecules were the ancestors to modern enzymes and worked alongside RNA catalytic units.

 JBC Podcast: Aminoacylating urzymes and the RNA world hypothesis -- an interview with Charles Carter of the University of North Carolina | File Type: audio/mpeg | Duration: 11:41

Sept 16 2013 — In this podcast we hear an interview with Charles Carter at the University of North Carolina who talks about his JBC Paper of the Week Aminoacylating Urzymes Challenge the RNA World Hypothesis The paper delves into how these peptide molecules were the ancestors to modern enzymes and worked alongside RNA catalytic units.

 JBC Podcast: Yeast, G protein and a family tradition in science -- an interview with new JBC Associate Editor Henrik Dohlman | File Type: audio/mpeg | Duration: 17:28

July 26 2013 — In this podcast we hear a conversation between John Kyriakis a longtime Associate Editor for The Journal of Biological Chemistry and Henrik Dohlman a professor of Biochemistry and Biophysics and of Pharmacology at the University of North Carolina at Chapel Hill Dohlman is one of nearly a dozen researchers invited in the past year to join the JBC Associate Editors He began his term on July 1 Here Dohlman talks about his longtime research in yeast G protein signaling pathways and feedback regulation He also talks about his longstanding family heritage in science his efforts to adapt to working with new genomics and proteomics tools and the future he sees both for JBC and the field of biochemistry.

 JBC Podcast: Vitamin C’s potential role in epigenetics | File Type: audio/mpeg | Duration: 05:52

May 10 2013 — In this podcast we hear an interview with Gaofeng Wang at the University of Miami Wang talks about his Paper of the Week Ascorbate Induces Ten-Eleven Translocation Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine The paper delves into how vitamin C may play a role in epigenetics.

 JLR Podcast: Fsp27 and fasting | File Type: audio/mpeg | Duration: 09:33

April 17 2013 — In this podcast we hear an interview with Pedro Marrero from the University of Barcelona about his group’s article in the Journal of Lipid Research Fsp2

 JBC Podcast: gedunin, Hsp90 and p23 | File Type: audio/mpeg | Duration: 11:51

In this podcast we hear an interview with Ahmed Chadli at the Georgia Regents University who talks about his Paper of the Week “Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis” The paper delves into the molecular mechanism of action of a naturally occurring product that is found in the neem tree an Indian medicinal plant.

 JBC Podcast: sirtuins and JBC's Best of 2012 | File Type: audio/mpeg | Duration: 15:48

In this podcast we hear an interview between JBC Associate Editor Joel Gottesfeld and John Denu from the University of Wisconsin-Madison about JBC’s Best of 2012 The Journal’s associate editors chose from among more than 4,000 articles published throughout the year selecting 22 one for each of the Journal’s affinity categories An affinity category corresponds to a section of the Journal’s table of contents. Denu co-authored two of the best of 2012 In the field of metabolism he coauthored the paper “Regulation of Glycolytic Enzyme Phyosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation,” which was published in February In the field of enzymology he coauthored the paper Sirt3 “Protein Deacetylates Isocitrate Dehydrogenase 2 and Regulates Mitochondrial Redox Status,” which was published in April.

 JBC Podcast: MDEG hyperactivation and caspase-8 activation | File Type: audio/mpeg | Duration: 11:47

Feb 1 2013 — Today we hear an interview with Wei-Xing Zong from Stony Brook University who talks about his group’s JBC Paper of the Week Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis The paper and interview investigate how misregulation of the degenerin family of ion channels leads to cell death.

 JBC Podcast: Parkin deficiency and myocardial infarction | File Type: audio/mpeg | Duration: 10:07

Jan 11 2013 — In this podcast we hear an interview with Åsa Gustafsson from the University of California San Diego who talks about her JBC Paper of the Week Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction The paper delves into the cardiac defects brought on by a protein involved in Parkinson’s disease.

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