JBC News Podcast: Key interactions at the HER2-HER3 kinase dimer interface: JBC’s best Signal Transduction article of 2013

Summary: March 3 2014 — In Part Three of our series of the best articles of 2013 in the The Journal of Biological Chemistry we hear a conversation between Alex Toker a professor in the Department of Pathology at Beth Israel Deaconess Medical Center and Ron Bose a medical oncologist and assistant professor in the Division of Biological and Biomedical Sciences at Washington University in St Louis Bose is the corresponding author of the paper “ Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface.” This paper was named the JBC’s Best Article of 2013 in the category of Signal Transduction The paper provides the first structural characterization of HER2-HER3 heterodimers which are part of the receptor family that is used in the development of targeted cancer therapies Here Bose talks about his more than 10 years of research in the study of tyrosine kinases He also talks about where the research is going the development of innovation where mass spectrometry is limited in the study of protein complexes that can’t be crystalized and the power of interdisciplinary studies for graduate students in science