ASBMB AudioPhiles

Dec 14 2012 -- In this podcast we hear an interview with Elena Hidalgo from the Unviersity of Pompeu Fabra in Barcelona Spain who talks about her JBC Paper of the Week Cells Lacking Pfh1 a Fission Yeast Homolog of Mammalian Frataxin Protein Display Constitutive Activation of the Iron Starvation Response The paper delves into the molecular biology of Friedreich ataxia a rare neurological disease.

May 4 2012 — In this podcast we hear an interview with Myron Goodman from the University of Southern California and David Rueda from Wayne State University who talk about the collaboration which led to their JBC Paper of the Week Singled-stranded DNA Scanning and Deamination by APOBEC3G at Single Molecular Resolution The interview and paper focus on the immunogenic effects of single-stranded DNA scanning enzymes; in particular with relation to HIV infectivity.

April 5 2012 — In this podcast we hear an interview with JBC Editor-in-Chief Martha Fedor who talks about the journal’s new honor the Best of 2011 Of the more than 4,000 articles published last year in The Journal of Biological Chemistry 20 were selected each representing a different affinity group.

March 9 2012 — In this JBC podcast we hear an interview with Jiou Wang from The Johns Hopkins University who talks about his group’s Paper of the Week “Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Lifespan.“ The paper and interview focus on the connection between neurodegeneration and aging.

January 3 2012 - In this JBC podcast we hear an interview with Joseph Jez from Washington University in Saint Louis who talks about his group's Paper of the Week "Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum an anti-parasitic drug target." The paper and interview discuss the role of lipid biosynthesis in malaria.

Nov 22 2011 -- In this podcast we hear an interview with Peter Hanley from the Institute for Molecular Cell Biology in Münster Germany who talks about his group's Paper of the Week "Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to C5a is PI-3K and p38 MAPK-independent." The paper and interview investigate the role of ATP in inducing the chemotactic response of macrophages during inflammation.

Aug 16 2011 -- In this podcast we hear from JBC Associate Editor Peter Guengerich about a recent thematic minireview series on the biological applications of mass spectrometry The discussion covers highlights from the minireviews in the series and the history of mass spec and the JBC.

Jul 7 2011 -- In this podcast we hear an interview by JBC Associate editor Jim Siedow with Riccardo Olcese of UCLA about his group’s Paper of the Week “Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.” The paper and their conversation covers the intriguing techniques used to uncover conformational changes in the powerful BK channel.Jul 7 2011 -- In this podcast we hear an interview by JBC Associate editor Jim Siedow with Riccardo Olcese of UCLA about his group’s Paper of the Week “Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.” The paper and their conversation covers the intriguing techniques used to uncover conformational changes in the powerful BK channel.

May 27 2011 -- This podcast features a conversation between JBC Editor-in-Cheif Martha fedor and Paper of the Week author Timothy Bowen of Cardiff University about his group's paper "The human hyaluronan synthase 2 gene and its natural anti-sense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell." The paper and their conversation covers the surprising role anti-sense RNA has taken on in the disease renal fibrosis.