Summary: On this episode, I discuss isosorbide mononitrate pharmacology, adverse effects, and important drug interactions. <br> <br> <br> <br> Isosorbide mononitrate is a vasodilator that works by relaxing and widening the blood vessels (primarily veins) through nitric oxide action. This reduces the preload and oxygen demand on the heart.<br> <br> <br> <br> The primary use for isosorbide mononitrate is angina prevention. It is important to remember that it is NOT meant for acute relief of chest pain.<br> <br> <br> <br> Headache is a major adverse effect of isosorbide mononitrate and can be very bothersome for patients. Vasodilation is primarily responsible for this adverse effect. <br> <br> <br> <br> PDE-5 inhibitors are notorious for causing drug interactions with any nitrate medication. I discuss management strategies in this podcast episode.
