Summary: On this podcast episode, I discuss glimepiride pharmacology, adverse effects, hypoglycemia symptoms, and drug interactions. <br> <br> <br> <br> CYP2C9 is an important enzyme in the breakdown of glimepiride. I discuss a few drugs that can cause interactions via this enzyme. <br> <br> <br> <br> Renal function is important to consider with glimepiride. The active metabolites are cleared by the kidney and can accumulate in CKD.<br> <br> <br> <br> Hypoglycemia and weight gain are problematic adverse effects of this medication and are the primary reasons it has fallen out of favor.
