Summary: Ranolazine is primarily used for chronic angina management. I discuss pharmacology, drug interactions, adverse effects, and more in this podcast episode.<br> <br> <br> <br> Ranolazine is well known to have drug interactions. CYP3A4 is of major importance but there are other subtle drug interactions that are important. <br> <br> <br> <br> QTc prolongation has been reported with ranolazine so it is important to recognize risk factors and other medications that may contribute to this concern. <br> <br> <br> <br> Enzyme inducers like carbamazepine, phenytoin, and St. John's wort are all associated with reducing the concentrations of ranolazine.
