Summary: Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and Perspective articles on physicians spreading misinformation on social media, on dietary supplements and institutionalizing misinformation, and on the portal. Supplement to the New England Journal of Medicine, Vol. 387, No. 1.
