Summary: Varenicline is a partial nicotine agonist that can be used to help patients quit smoking. <br> <br> <br> <br> The two most common adverse effects that I have seen in clinical practice with varenicline are GI upset and insomnia/vivid dreams. <br> <br> <br> <br> GI upset with varenicline can be reduced by giving the drug with food and a full glass of water. A dose reduction may also be considered.<br> <br> <br> <br> Patients should identify a goal stop date for smoking cessation prior to begininng the use of varenicline.
