Summary: <br> <a href="https://twitter.com/intent/tweet?url=http%3A%2F%2Fwww.talkingbiotechpodcast.com%2F268-what-is-an-mrna-vaccine%2F&via=talkingbiotech" class="twitter-share-button" data-size="large">Tweet</a><br> <a href="https://i0.wp.com/www.talkingbiotechpodcast.com/wp-content/uploads/2020/11/268-mRNAvac-cover.jpg"></a><br> mRNA vaccines have recently been in the news as an exciting potential preventative of SARS-CoV2. The technology seems new, but has roots in the 1990’s and a long history of maturation, plagued by technical barriers and skepticism. However, the efficacy demonstrated in clinical trials is promising, and suggests that mRNA-based strategies may have a prominent role as vaccines and therapeutics against some of our most insidious diseases.<br> <br> Resources for this podcast:<br> <a href="https://pubmed.ncbi.nlm.nih.gov/7958480/">Hilleman 1994</a> – a conceptual review of the potential for mRNA vaccines, predicing many of its challenges.<br> <a href="https://www.cell.com/immunity/fulltext/S1074-7613(05)00211-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761305002116%3Fshowall%3Dtrue">Kariko et al, 2005</a> – This paper contains information on how mRNA may be modified to limit its inherent antigenic activity.<br> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597572/#R3">Schlake et al., 2012</a> – A very good primer to the history and theory of mRNA vaccine development.<br>
