Summary: Metolazone (Zaroxolyn) is a thiazide-like diuretic. It promotes the loss of water and sodium through the kidney. <br> <br> <br> <br> The most common indication I see metolazone used for is for additional fluid loss in heart failure. <br> <br> <br> <br> Potassium must be monitored as it can cause significant hypokalemia which is exacerbated when metolazone is used in combination with loop diuretics. <br> <br> <br> <br> Hyperuricemia is a potential adverse effect with metolazone; this is critical to monitor for in patients at risk for gout attacks.
