Summary: Trazodone pharmacology is complex. It can inhibit serotonin reuptake, block histamine receptors, and possibly have alpha-blocking activity.<br> <br> <br> <br> Side effects of trazodone include sedation, dizziness, and dry mouth. Rarely, priapism may occur. I've seen this nugget come up on pharmacology exams!<br> <br> <br> <br> While trazodone is classified as antidepressant, it is often used to help manage insomnia.<br> <br> <br> <br> Trazodone can possibly prolong the QT interval. Risk of other medications and patient specific parameters should be considered.<br> <br> <br> <br> Trazodone concentrations can be increased with the use of CYP3A4 inhibitors and reduced with 3A4 inducers.
