Summary: Jim Goetz We begin the show by stating that eveything discussed is for education purposes only. Nothing contained in the biohackhumans podcast are intended to diagnose, treat or cure any disease. Seek out the care of a competent health care provider. Biohackers Inc is a 501c3 non profit organization. To keep bringing top notch education each week, we are requesting donations. Patrons may receive shout outs, biohackers gear, spots on the show and advertising. If you enjoy the show, we ask you not only ensure all your friends and family subscribe on iTunes, Google Play or iHeart Radio and very soon Spotify, but also to leave an honest 5 star review. We are joined this week by top New Jersey personal trainer Jared Rappoport. Jared currently trains at Ovox Gym in Morganville, New Jersey. Jared specializes in both body building and total body transformations. He has been a personal trainer for over a decade and there's no slowing down now. Clients and patients alike both bring up different ideas and concepts they hear about that they are unsure about. As individuals are always lookig for the competitive edge, more and beginning to turn to SARMS, which is an acronym for Selective Androgen Modulator Receptors. These chemicals have been around since the 1940's but really only have become a part of the main stream (filled with controversey) since the 1990's. The initial purpose of the development of SARMS was to treat a plethora of diseases such as cancer, hypogonadism, osteoporosis, Alzheimers, catexia and more. The best way to describe how SARMS work is to think of them as a puzzle piece. These puzzle pieces can only fit into specific slots in your body (receptor sites). Therefore, SARMS may float around the body and do nothing until they attach themselves to the appropriate receptor site, unlocking specific aspects of ones DNA such as preventing muscle and bone wasting. In comparing SARMS to testosterone cypionate, it appears SARMS may actually be 200 times more anabolic and 80 times more selective for the receptor sites. This means side effects are limited at best as compared to anabolic steroids for the treatment of diseases. While most research on SARMS has been conducted in lab mice, phase 1 trails on humans have begun. This is why SARMS are only available for purchase for research purposes only and not for human consumption. Some of the most popular SARMS are: LGD-4033- prevents catexia by enhancing lean muscle mass and reduces body fat. MK-2866- also prevents catexia by maintaining and increasing lean body mass and recomping. S4- designed to cure osteoporosis and increases bone density RAD140- possible cure for Alzheimers A substance which is in the SARMS family but would be considered more of a distant cousin as it's not technically a SARM is GW 501516. This may greatly increase ones physical endurance and is one of the two substances used and detected that had top 2017 Cross Fit Games athlete Ricky Gerard disqualified, suspended and outcasted by his peers. However, until the detection of this substance, he was giving 3 time Cross Fit Games Champion Mat Fraser, a run for his money. Some benefits of SARMS are: Non-toxic. Prevents calcium depletion (bone loss). Decreases the risk of prostate dysfunction. Will not interfere with ones HPTA. Will not convert to estrogen. Some human performance benefits include: Increased muscle strength. Increased muscle size. Tissue selective. Inhibits cancer cell division. Regulates libido. Side Effects of SARMS I would like to be able to comfortably list the known side effects of SARMS but in reality, thus far long term research has not been available to understand what these effects may be. Any known side effects may occur due to unregulated SARMS being laced with anabolic steroids and pro-hormones. This is why if a qualified individual does research on SARMS, they should ensure the laboratory they obtain their research chemicals from is up to par. Ethics of Using SARMS, HGH and Steroids in Sports This is a highly controversial and debatable topic. Individuals ask all the time what they should take. My advice (Jim Goetz) is to wake up each morning and have a very large glass of hard work. One should have a steady diet of determination and persistence. Supplements, SARMS, steroids, HGH and the like are often relied upon to get an athlete to the level of super human. However, when relied upon, one never achieves their true potential. While certain substances such as human growth hormone may prolong the careers of many athletes, especially foot ball players, due to the ability to speed healing, it is still a banned substance in the NCAA and National Football League. Any banned substance on the list provided by the World Anti- Doping Association should be avoided by any athlete competing in a sport they may be tested in. When one tests positive, they not only lose the chance to maximize their profits to play a game, but may result in suspension and become ostrasized by your peers. So many athletes believe they will never be caught. No one is smarter than the system as someone some where will do something and then rat them out. While some substances may actually be legal in certain sports, remember that how one obtains them must also be legal. Buying steroids from the shady guy in the gym is illegal!!! As we state in the beginning of each show, ensure you contact a qualified and good health care provider and not get your information from uneducated meat heads on a blog somewhere that have never truly accomplished anything in their lives other than huge arms that may have impressed girls back in undergrad. Anti-Aging This topic could literally be the topic all podcasts are dedicated to as it is such an emerging field in medicine yet humans have been chasing anti-aging and ways to remain young forever since the dawn of time. From Ponce de Leon and his search for the Fountain of Youth to the mention of the philosophers stone going back to 300 A.D., mankind has been searching for ways to remain youthful. Why would one not want to remain youthful and vibrant for an eternity? Aging brings reduced cognitive function, diminished strength, speed and endurance, aches and pains and diseases and ultimately death. Why would anyone want this? Some aspects of anti-aging are mere superficial remedies such as botox or using ceremides to reduce wrinkles. None of these treatments though slow down the reduction of telmomeres. It's been theorized that telomeres in our DNA reduce in length with age. It's like our internal clock. Once the telomeres are gone, the cell dies. Humans are made of cells. Therefore, once the telomere countdown ends, we die. Some methods though that are being realizes to help prolong life are not drug related. Believe it or not they are natural things we can do each and every day. Some believe that statins help prevent heart attacks but now being shown that not only do they not prevent heart attacks like previoulsy believed but reduce cognitive function, increase idiopathic muscular pains and even reduce longevity. The popular diabetes drug metformin is theorized to reduce the rate of telomere shortening. If one begins metformin at the age of three (3) they may life to 120 to 150 years of age. However, metformin does not come without side effects. Berberine has been shown to have these same effects as metformin though and without the harmful side effects. Other methods to delay telomere shortening are: -calorie restriction (see the biohackhumans podcast on intermittent fasting and the future podcast on autophagy). -proper anti-oxidant intake (not simply a cheap multi- vitamin). This may reduce aging through oxidation and fight reactive oxygen species (ROS). As we age, hormones are reduced. When we have lab work done, physicians typically look at ones hormone levels as compared to the age they are. One feels much different though at the age of 25 than they do at 65. Individuals may utilize hormone replacement therapy to match their hormones to that of the age of 25 and perform as they did at this age. Activities of daily living become easier and more fulfilling. DHEA may improve memory, immune function, muscle mass, libido and the endocrine system. Melatonin is now being understood to have some anti- oxidant characteristics in addition to improve circadian rythms. While melatonin thus far has been unsuccessful in preliminary research to show increases in life span, it is being used now in cancer treatments (mega doses) and may improve ones daily life through increased cognitive function by improving sleep. Pregnenalone is another natural substance that is the precursor to 50 other hormones that are often reduced with age. . In females, estrogen therapy has been shown to be beneficial to increase bone density and protects against heart disease. Stem cell therapy may help regenerate cells to prevent cardiovascular disease and improve or eliminate autoimmune diseases. It has been found in preliminary research that messenchymal stem cells of younger donors (mice) estends the lifespan in older recipients. ALT-711 may be useful in preventing heart disease by reducing pulse prressure and improving arterial elasticity. This occurs through breaking advanced glycosylation end product crosslinks. There are some current anti-aging developments but not worth mentioning until further credible research is completed. At the end of the day, so far there is no magic bullet of anti-aging. If the fountain of youth truly exists, then perhaps a glass of water each day from it will allow us to live for eternity. Until then, understanding the information listed above in addition to a diet that consists of organically grown produce rich in phytonutrients, a non-processed ketogenic diet, limiting alcohol intake, not smoking, and moderate exercise each day. Observational studies do show that individuals who laugh, smile and have purpose in life end up living longer than those who are unhappy and lack ambition. In the coming weeks, myself the madscientist Jim Goetz, Dr. Mike Brandon and Beauty, Brains, Brawn Chantea Goetz will be discussing more on concussion testing, protocols and utilizing the services of expert health care providers to ensure healthy cognitive function after a traumatic head injry (any blow to the head is traumatic). We will also be discussing energy levels and adrenal dysfunction. Some call adrenal dysfunction, adrenal fatigue, but we will dispell this terminological snafu. biohackhumans.com Find us: Instagram (@biohackhumans) Facebook (@biohackhumans) Twitter (@biohackhumans) Tumblr (@biohackhumans) Contact Us: support@biohackhumans.com
