Summary: If you have sickle cell disease, that means you have a 1 in 10 chance of experiencing a stroke before college. And if you don't think that's going to hold you back, you don't know stroke. This week on BrainWaves, Dr. Erica Jones shares her experience with the neurologic complications of sickle cell anemia, and the latest guidelines for managing patients with this condition. BrainWaves podcasts and online content are intended for medical education only and should not be used to guide medical decision making in routine clinical practice. REFERENCES 1. "Data & Statistics." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 31 Aug. 2016. Web. 04 Dec. 2016. 2. Wang WC, Dwan K. Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD003146. DOI: 10.1002/14651858.CD003146.pub2. 3. Motulsky, Arno G. "Frequency of Sickling Disorders in U.S. Blacks." New England Journal of Medicine 288.1 (1973): 31-33. Web. Dec. 2016. 4. Lionnet, F., N. Hammoudi, K. S. Stojanovic, V. Avellino, G. Grateau, R. Girot, and J.-P. Haymann. "Hemoglobin sickle cell disease complications: a clinical study of 179 cases." Haematologica 97.8 (2012): 1136-141. Web. Dec. 2016. 5. Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, Wethers DL, Pegelow CH, Gill FM. “Cerebrovascular accidents in sickle cell disease: rates and risk factors.” Blood. 1998;91(1):288 Dec. 2016. 6. Bang, Oh Young, Miki Fujimura, and Seung-Ki Kim. "The Pathophysiology of Moyamoya Disease: An Update." Journal of Stroke 18.1 (2016): 12-20. Web. Dec. 2016. 7. Gueguen, Antoine, Matthieu Mahevas, Ruben Nzouakou, Hassan Hosseini, Anoosha Habibi, Dora Bachir, Pierre Brugière, François Lionnet, Jean-Antoine Ribeil, Bertrand Godeau, Robert Girot, Vahid Ibrahima, David Calvet, Frédéric Galactéros, and Pablo Bartolucci. "Sickle-cell disease stroke throughout life: A retrospective study in an adult referral center." American Journal of Hematology 89.3 (2014): 267-72. Web. Dec. 2016. 8. Scott, R. Michael, and Edward R. Smith. "Moyamoya Disease and Moyamoya Syndrome." New England Journal of Medicine 360.12 (2009): 1226-237. Web. Dec. 2016. 9. Switzer, Jeffrey A., David C. Hess, Fenwick T. Nichols, and Robert J. Adams. "Pathophysiology and treatment of stroke in sickle-cell disease: present and future." The Lancet Neurology 5.6 (2006): 501-12. Web. Dec. 2016. 10. Verduzco, L. A., and D. G. Nathan. "Sickle cell disease and stroke." Blood 114.25 (2009): 5117-125. Web. Dec. 2016. 11. Ware, R. E., and R. W. Helms. "Stroke With Transfusions Changing to Hydroxyurea (SWiTCH)." Blood 119.17 (2012): 3925-932. Web. Dec. 2016. 12. Strouse, John J., Sophie Lanzkron, and Victor Urrutia. "The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease." Expert Review of Hematology 4.6 (2011): 597-606. Web. Dec. 2016.
