Summary: What makes an angry drunk? Ethanol inhibits the methyl cycle over time because it depletes nutrients important (including methylfolate, magnesium, methylcobalamin, and Vitamin B2 aka riboflavin). This slows methylation, which is needed to decrease epinephrine and norepineprhine levels. Alcohol also causes increased urination and increased loss of magnesium, which is necessary for proper methylation. Histamine and tyramine are high in some alcohols, especially aged alcohols (red wine). MAO (monoamine oxidase) is the enzyme needed to break down amines. This enzyme is generally slower in men than women.
