Summary: Niacin (Vitamin B-3) is involved in over 400 biochemical reactions in the body! As with other nutrients, methylfolate and niacin levels need to be in balance. High doses of specific nutrients will push certain biochemical pathways more than others. This is why niacin can be used to offset methylfolate side effects. Niacin deficiency can cause: irritability, headaches, migraines, and possibly skin issues.
