The Cannabis Consult w/ Dr. Jamie Corroon, ND, MPH

Dr. Sexton is the Endocannabinoid System Doctor (ecsdoctor.com). She is Assistant Adjunct Professor at UCSD in the Department of Anesthesiology. She graduated from Bastyr University in 2008. She completed a postdoctoral fellowship at the University of Washington where she formally studied the endocannabinoid system for 6 years. Her NIH-funded pre-doctoral and postdoctoral research on the topic of cannabinoids and their roles in neuroinflammation and neurodegeneration investigated cannabis use and impact on inflammatory markers. She has continued her research into health effects of cannabis at UCSD. Prior to medical school, she was a midwife and herbalist for 15 years. Dr. Sexton has presented he research internationally and published in peer-reviewed journals. Dr. Sexton’s clinical practice, research and teaching focus on the endocannabinoid system and roles for integrative medicine, including cannabis to treat a range of conditions across the lifespan. She is a member of the International Cannabinoid Research Society, the International Association of Cannabinoid Medicine The Society of Cannabis Clinicians and the American Association of Naturopathic Doctors. She is a Board Member on the California Association of Naturopathic Doctors. She maintains a medical practice in the Pacific Beach neighborhood of San Diego, CA.When not caring for patients or pursuing research activities, you can find her in the garden, paying music, playing with grandchildren, swimming or riding her bike to the beach for a surf session! Part 1 1:40 - Michelle’s background 5:00 - Immunity, inflammation and the CB2 receptor 6:22 - The endocannabinoid & immune systems 7:00 - CB2 receptors on white blood cells 10:00 - Cross-talk between systems, TNF-alpha 10:40 - What is immune suppression? Is it good? 12:30 - CBD and inflammation. Measuring the CB2 receptor 14:35 - CBD and other receptors 14:50 - TRPV1 receptor 15:50 - Cannabis modulating the immune system 18:20 - Cannabinoids and COVID-19 20:00 - Dosing of THC 21:05 - The role of TNF-alpha 23:35 - Sepsis 25:00 - Smoking & risks of complications 27:12 - Cannabinoids won’t protect you from COVID-19 Michelle Sexton’s clinical practice: http://www.msextonnd.com Online course: Women's Health and Cannabis Across the LIfespan and Endocannabinoid System 101 https://ecsdoctor.teachable.com

Dr. Sexton is offering $50 off (33% discount)for her online course: Women's Health and Cannabis Across the LIfespan and Endocannabinoid System 101 Code: WOMEN Dr. Sexton is the Endocannabinoid System Doctor (ecsdoctor.com). She is Assistant Adjunct Professor at UCSD in the Department of Anesthesiology. She graduated from Bastyr University in 2008. She completed a postdoctoral fellowship at the University of Washington where she formally studied the endocannabinoid system for 6 years. Her NIH-funded pre-doctoral and postdoctoral research on the topic of cannabinoids and their roles in neuroinflammation and neurodegeneration investigated cannabis use and impact on inflammatory markers. She has continued her research into health effects of cannabis at UCSD. Prior to medical school, she was a midwife and herbalist for 15 years. Dr. Sexton has presented he research internationally and published in peer-reviewed journals. Dr. Sexton’s clinical practice, research and teaching focus on the endocannabinoid system and roles for integrative medicine, including cannabis to treat a range of conditions across the lifespan. She is a member of the International Cannabinoid Research Society, the International Association of Cannabinoid Medicine The Society of Cannabis Clinicians and the American Association of Naturopathic Doctors. She is a Board Member on the California Association of Naturopathic Doctors. She maintains a medical practice in the Pacific Beach neighborhood of San Diego, CA.When not caring for patients or pursuing research activities, you can find her in the garden, paying music, playing with grandchildren, swimming or riding her bike to the beach for a surf session! Part 2 1:55 - Cannabis & pregnancy 3:30 - Menstrual cramps 5:00 - CBD & smooth muscle spasms 7:00 - CBD dosing 9:00 - What is bioavailability? 9:35 - Suppositories 12:30 - Michelle’s online course on the ECS and women’s health 18:00 - The Endocannabinoid System 18:50 - Beta-caryophyllene as a dietary cannabinoid 21:09 - Clinical Endocannabinoid Deficiency 23:20 - Hyperemesis gravidarum (Nausea and vomiting during pregnancy) 26:50 - Overall thoughts on cannabis & women’s health Michelle Sexton’s clinical practice: http://www.msextonnd.com Online course: Women's Health and Cannabis Across the LIfespan and Endocannabinoid System 101 https://ecsdoctor.teachable.com Papers mentioned: Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? https://www.ncbi.nlm.nih.gov/pubmed/15531501

In his role as Director of Innovation, Mike Hennesy continues to position Wana Brands on the leading-edge of cannabis science and technologies as the market leader in infused product innovation. Hennesy oversees a diverse range of responsibilities including research and development, business analytics, training programs, and strategic partnership building. Hennesy developed Wana’s online interactive training program for budtenders and employees that covers the science of the endocannabinoid system. He also directed the development of Wana’s disposable vape line, including the line’s unique proprietary blend. Prior to his role as Director of Innovation managed a sales team of seven and has been instrumental in Wana’s availability in the vast majority of Colorado’s dispensaries and three-year growth rate of 269%. A native of Northern Virginia, Hennesy graduated from The University of Maryland with a Bachelor of Science in Environmental Science and Technology (ENST) in 2012. He is currently enrolled in a Master Program for Cannabis Science and Therapeutics at The University of Maryland’s School of Pharmacy. Hennesy served as Vice President of the ENST Society and was an active member of the Washington, D.C. chapters of NORML and Students for Sensible Drug Policy (SSDP). Hennesy brings a diverse background to the industry as a certified Rescue Diver, Eagle Scout and outdoorsman. When not working, he still finds time for camping, hiking and snowboarding in the mountains around Boulder, Colo. 01:58 - The University of Maryland Masters of Science Program in Medical Cannabis Science and therapeutics 02:54 – Background on Wanna Brands, a Colorado-based manufacturer of edible cannabis products 04:18 – Dr. Corroon’s background in Naturopathic Medicine and public health. How he entered the field of medical cannabis. 13:54 - How cannabis plays a role in treatment plans and patient recommendations 17:45 - CBD and THC ratios 20:16 – Dr. Corroon’s research 23:33 - Clinical research and pharmacology utilizing isolated cannabinoids versus extracts 25:14 - Research into hemp-derived CBD products 26:46 – Limitations in using CBD and THC in clinical practice 29:18 – Future directions in cannabis research 31:35 – The need for education in medical cannabis 34:24 - Future plans for the Center for Medical Cannabis Education 35:25 – Soon-to-be-published research by Dr. Corroon 37:51 – Hemp-derived CBD products are everywhere 38:56 – Health-related claims on labels of cannabis products

Greg Tilford is a leading force and early pioneer in the field of veterinary botanical medicine. His 24 years of professional experience as a formulating herbalist and educator began while living off the grid for 11 years in the rugged mountains of Montana. There he engaged in an intensive study of medicinal plants, their human and animal uses, and the intricate, interconnected relationships that exist between all living things that depend upon them. His work transcends conventional science to explore the roles of plants and animals as teachers and keepers of planetary wellness. Greg has authored four books, including the acclaimed “Herbs for Pets, The Natural Way to Enhance Your Pets Life” and dozens of published articles. In recent years he has been traveling the world, teaching and lecturing to audiences ranging from lay pet owners to veterinarians and institutions of higher education as far away as Japan, Taiwan, Thailand and Central America. Part of his outreach effort is bringing bioregional herbalism into awareness, so common plants can be accessed and safely used in the care of animals anywhere, even in the most impoverished regions. Greg’s most current work focuses on the human-animal bond, and how plants, animals and earth are interlinked. Greg is the co-founder and president of Animal Essentials, a company that has been manufacturing natural pet supplements since 1995. 1:15 - Greg's background 3:40 - Plants & animals 5:10 - Evidence for plant medicine 7:23 - Isolates v. extracts 11:00 - Safety of herbal extracts 12:30 - National Animal Supplement Council adverse events reporting system 16:10 - Learning to write 19:45 - Working w/ Vets, Animal Essentials 21:10 - Animal Essentials hemp products 26:00 - European hemp pedigrees 27:20 - CBD in pets 33:10 - Dosing CBD in pets 42:23 - Vet education on the endocannabinoid system 45:10 - Vets using THC in animals 46:00 - Adverse effects of CBD in animals 46:50 - Conditions being treated in animals 48:12 - Sourcing CBD, quality control 49:20 - Hemp v. marijuana 53:25 - Using leaf v. flower 54:25 - Future directions for Animal Essentials 55:39 - Azadirachtin in neem oil (Pesticide) 56:36 - Organic certification of hemp

Mr. Tomc is the Vice President of Human Nutrition at CV Sciences. He is a recognized authority on dietary supplements, with twenty years of experience in the nutritional health industry. Formerly the Vice President of North American Herb and Spice, where he served for 10 years, in addition to his service as Global Educator for omega-3 market leader, Nordic Naturals, Mr. Tomc is known for his extensive print interviews and contributions to noted books on integrative medicine, as well as his 4,000 radio appearances. A renowned educator, Mr. Tomc recognizes CBD and its multiple mechanisms of action to support human health, and envisions a new category of dietary supplements derived from agricultural hemp. Topics: 2:35 - From Omega 3 to CBD 4:30 - Eicosanoids and endocannabiods 8:15 - Who is CV Sciences? 12:00 - Regulatory status of CBD and hemp 17:20 - Who is the US Hemp Roundtable 21:14 - Over-the-Counter CBD products 23:35 - Marijuana-dervied CBD 26:35 - Great efficacy w/ terpenes? 29:30 - Isolated CBD v. whole-spectrum CBD 40:00 - Sativex v. Dronabinol 41:00 - Toxicology & safety of hemp extracts 44:00 - GRAS designation 50:00 - NOAEL (No-observed-adverse-effect level) 54:00 - Rescheduling of CBD 60:00 - Regulatory status of CBD post-Epidiolex Studies mentioned in this podcast: Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

Dr. Aimée is a naturopathic physician in private practice since 2001, currently at Santa Cruz Integrative Medicine in Santa Cruz, California. She completed her undergraduate studies at Vanderbilt University where she graduated cum laude with a BA in psychology and minors in theatre and women’s studies. After several years of working with teens in residential treatment facilities, she returned to school for her postgraduate pre-medical coursework, and then attended the National College of Naturopathic Medicine where she received her naturopathic medical degree. Dr. Aimée continues to pursue additional postgraduate education with the Institute for Women's Health and Integrative Medicine, International Society for the Study of Women's Sexual Health, Academy of Integrative Health and Medicine, and others. https://www.drshunney.com Topics: 1:50 - Using CBD with patients. The beginning. 6:00 - Getting "high" on CBD 7:50 - THC-like effects using CBD 11:00- Endocannabinoid tone 12:15 - Starting dose of CBD 14:00 - Whole-plant extracts v. isolates 16:00 - Too much THC in your CBD product 17:40 - Endocannabinoid tone explained 21:00 - Drug interactions 22:20 - Low, medium and high doses of CBD 25:00 - Cost of CBD products 26:00 - Marijuana-derived CBD v. hemp-derived CBD

Dr. Monica Vialpando is a pharmaceutical development scientist and principal at Vialpando LLC, a provider of outsourced innovation consulting for the cannabis industry. She has seven years of pharmaceutical industry experience, four years of vaping (nicotine) experience and two years of cannabis product development experience for a variety of US, UK, European and Asian-based companies. Her development portfolio includes immediate and modified release oral tablets, sublingual tablets, dry powders and nebulizer solution for inhalation, nicotine and cannabis vape products and topicals. She was awarded her Ph.D. in Pharmaceutical Sciences from the University of Leuven, Belgium. Topics: 5:42 - Solubility and bioavailability 8:42 - Pharmacokinetics and dynamics 10:28 - Increasing the bioavailability of cannabinoids 13:00 - Formulating using pharmacokinetics and pharmacodynamics 15:00 - Cannabindoids in oral tablets 20:40 - Customer/Patient feedback on products 23:05 - Lessons from the c-cigarette industry 25:00 - Dilutants and propellants in vape cartridges 31:0 0 - MCT oil in vape cartridges 34:40 - Dr. Corroon's clinical practice 37:00 - Therapeutic use of other cannabinoids

Dr. Kevin Spelman is an internationally recognized expert on the molecular biology and clinical therapeutics of botanical medicines and new product development. A past National Institutes of Health postdoctoral fellow and Marie Curie research fellow in the European Union, he has published 27 scientific papers and 6 chapters. Dr. Spelman has also practiced clinical phytotherapy for 20 years in various medical centers as well as advised the White House Commission on Complementary and Alternative Medicine and most recently was invited to the White House Office of Science and Technology Policy conference on the microbiome. Dr. Spelman has also consulted for the Department of Defense on specific therapeutic outcomes using natural products. Past research projects have included the elucidation of various phytochemicals influencing endocananbinoid signaling, the molecular biology of cannabinoid receptors, and being the first researcher to elucidate cannabinoid ligands in Zanthoxylum spp. Other research has included brain and ovarian cancer, clinical investigations, immunological studies and chemical analysis on multiple medicinal plants. Dr. Spelman is an adjunct assistant professor at Massachusetts College of Pharmacy and Health Sciences, an adjunct professor of botanical medicine at National College of Natural Medicine and a distinguished lecturer at Maryland University of Integrative Health. Topics discussed: Functions of terpenes & terpinoids in nature Physiological effects in humans Herbal synergy (i.e. The Entourage Effect) Sativa v. Indica Safety of inhaling terpenes Terpenes in concentrates

Dr. Strause is the Principal and Founder of Strategic Clinical Consultants with over 25 years’ experience in the biopharmaceutical industry. She is considered to be at the top in her field and overseas the conduct of large global clinical trials primarily in cancer research. In addition, she is an Adjunct Professor of Human Nutrition at the University of California San Diego. Dr. Strause spent over 15 years volunteering and working for San Diego Hospice to advance research into end of life care. She brings professional expertise as an expert in ethical oversight and human subject protection as well as her personal journey with her husband through his diagnosis and death from incurable brain cancer, GBM. Dr. Strause is the Vice President of Randy's Club, a manufacturer of botanically complete products that contain naturally occurring cannabinoids from hemp.

Dr. Jake Felice, N.D., L.M.P. is a charismatic public speaker and social media expert on the topic of medical cannabis. As a consultant and national cannabis brand ambassador, Dr. Felice provides scientific, medical, public relations, and compliance based advice for companies in emerging and existing cannabis markets. http://cannabismatrix.com