New Study Explores the Genetic and Causal Links between Migraine, Inflammatory Bowel Disease, and Celiac Disease

Summary: Celiac.com 07/10/2023 - Previous observational studies have suggested links between migraine, inflammatory bowel disease (IBD), and celiac disease. However, it remained unclear whether these associations were due to shared genetic factors or if there was a causal relationship. Understanding these connections could have implications for treatment and symptom management. A research team recently aimed to investigate the possible genetic and causal connections between migraine, inflammatory bowel disease, and celiac disease. To do this, they conducted a Mendelian randomization study using data from various genome-wide association studies. The Research Team The research team included Nike Zoe Welander MSc, Gull Rukh PhD, Mathias Rask-Andersen PhD, Aster V. E. Harder MSc, MD, The International Headache Genetics Consortium, Arn M. J. M. van den Maagdenberg PhD, Helgi Birgir Schiöth PhD, and Jessica Mwinyi MD, PhD. They are variously affiliated with theDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; the Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden; the Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; and the Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. The Study - Statistical Analyses to Assess Genetic Correlation and Causality Their study analyzed data from over 60,000 migraine cases, 25,000 inflammatory bowel disease cases, and 12,000 celiac disease cases, along with their respective control groups. Different subtypes of migraine and inflammatory bowel disease were also considered separately. The researchers used specific statistical analyses to assess genetic correlation and causality. The Findings - No Genetic Correlation The findings showed no genetic correlation between migraine and inflammatory bowel disease or celiac disease when all participants with migraine were analyzed together. There was also no evidence of inflammatory bowel disease or celiac disease causing migraine, or migraine causing inflammatory bowel disease or celiac disease. Causal Associations Between Celiac Disease and Migraine However, the study did indicate some potential causal associations between celiac disease and migraine with or without aura, as well as between migraine without aura and ulcerative colitis. It is important to note that these associations did not reach statistical significance after adjusting for multiple testing. In conclusion, this study did not find evidence of a shared genetic basis or a causal relationship between migraine and either inflammatory bowel disease or celiac disease. Although there were indications of potential causal associations with specific subtypes of migraine, further research is needed to confirm these findings and explore the underlying mechanisms. Read more in headachejournal.onlinelibrary.wiley.com