Understanding The LD50 Lethal Dose 50

Summary: Stephen Vantassel here wildlife control consultant. Wanted to talk today about L.D. 50 and understanding LD 50 as motive. Many of you know I’m involved in vertebrate control so the role of pesticides to control vertebrates raises a lot of issues and concerns about the relative toxicity of some of these toxic loans fume against that are being used to control unwanted pest vertebrates. So let’s back up a little bit and talk about the relationship between notions of risk and harm. Now on another podcast I would kind of been deep in the notion of risk here, I’m not gonna go as far deep into that as before but I do want to give you concept to help you understand the difference between understanding risk and understanding what harm is. Because these are two different concepts. Risk is the probability or the potential for a negative event or the probability of harm that something bad is going to happen harm. The concept of harm is what is the actual effect of that negative event so risk is the potential. The likelihood that something bad is going to happen harm is it is an analysis or discussion of what that actual negative event actually is. So when we’re talking about LD 50. We really focusing in we’re drilling down on this notion of harm. What is this. What is the harmful Effects of this particular toxic and or fumigate or many of your cases because many of you deal with bugs of this particular pesticide. So let’s kind of drill into that a little bit now if you’re heard by other podcast you would have heard me talk about how hazard or risk is exposure times toxicity. And so we’re going to be focusing not on the exposures side but we’re going to be focusing on the toxicity side. That’s that that harm element of this particular toxicity. How lethal is this particular element. And even under toxicity we have to be breaking it down a little bit more. Our focus is going to be on its lethality not the toxicity in terms of its persistence. That’s a different question. We’re looking at the acute effects of the problem not the long term effects. Now acute effects are typically defined in pesticide use as what the effect of a pesticide is that occurs within twenty four hours Long. The long term effects are beyond 24 hours in some cases some pesticides may have effects for years. But when we’re dealing with LV 50s we’re looking at acute toxic effects. All right so let’s kind of talk about Understanding relative toxicity. Now L.D. 50 which stands for Lethal Dose 50 percent it’s symbolized as capital L capital D with a subscript number of 50 Five 0. That’s typically how it sits it’s so we call it L.D. 50 Lethal Dose 50 percent. Now what it is it’s a a formulaic way to give a number to how potentially lethal this particular product is and it’s often given in the sense of milligrams per kilogram. How much is needed to kill 50 percent of the test subject. So if you have 20 animals how many how much of the dose at a 50 milligram per kilogram rate do you need to kill 50 percent of those animals which would be in this case 10 so let’s talk about milligrams and kg so a milligram is one millionth Of a kilogram. Now if you’re trying to we know

Understanding The LD50 Lethal Dose 50

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