An International Journal of Toxicology Podcast: Putative Mechanisms of Environmental Chemical-Induced Steatosis

Summary: This podcast features Dr. J. Philip Kaiser discussing his recent paper "Putative Mechanisms of Environmental Chemical-Induced Steatosis", published in vol. 31(6) of International Journal of Toxicology". Steatosis, also known as fatty liver, can progress to a form of hepatitis, and eventually to fibrosis and cirrhosis of the liver. While alcohol consumption, metabolic syndrome, and hepatitis are common causes of liver disease, this study examined environmental chemicals in the US EPA's Integrated Risk Information System (IRIS) that induce steatosis, and investigated possible cellular and subcellular mechanisms by which the chemicals could be acting.