Science Signaling Podcast

Eric Haura and Matthew Smith describe a new assay that could improve identification of tumors that are likely to respond to therapies that inhibit epidermal growth factor receptor (EGFR) signaling.

Scott Earley explains how reactive oxygen species activate TRPA1 ion channels to trigger dilation of cerebral arteries.

Kris Wood discusses two new studies that reveal potential ways to overcome drug resistance in cancer.

Benjamin Tu discusses how Npr2 and TORC1 control the ability of yeast to synthesize and utilize glutamine when the cells are grown on a nonfermentable carbon source.

Natalia Jura and Peter Littlefield explain how mutations in the catalytically inactive epidermal growth factor receptor HER3 enhance its ability to stimulate signaling by other members of this family of recptors.

Catherine Wasser and Joachim Herz have found that normal synaptic function and fear learning require glycosylation of the apolipoprotein E receptor Apoer2.

William Pryor and Srinivasa Subramaniam report that a mutant form of huntingtin that is associated with early-onset Huntington's disease promotes anabolic signaling that contributes to disease symptoms in mice.

Kai-En Chen, Tzu-Ching Meng, and Andrew Wang discuss their crystal structure of the kinase p38γ bound to the phosphatase PTPN3.

Amnon Altman describes how the guanine nucleotide exchange factor SLAT binds to IP3 receptor 1 at the endoplasmic reticulum to promote calcium release and T cell activation.

Michael Simons describes how signaling through the receptor FGFR1 prevents endothelial-to-mesenchymal transition by inhibiting TGF-β signaling.

Shulamit Michaeli talks about how the Trypanosoma brucei kinase PK3 inhibits new protein production in response to endoplasmic reticulum stress.

Al Singer, Gil Katz, and Leonid A. Pobezinsky talk about how signaling through the T cell receptor inhibits interleukin-7 receptor signaling.

Carla Rothlin and Sourav Ghosh discuss why atypical protein kinase C is a promising target for treating glioblastoma.

Will Talbot discusses how collagen binds to and activates the orphan receptor GPR126.

Juliane Mooz and Krishna Rajalingam discuss how the kinase ARAF promotes the MAPK pathway activation and cell migration induced by BRAF inhibitors.