Science Signaling Podcast
Summary: Periodic audiocasts from Science Signaling, the leading journal of regulatory biology and cell signaling in physiology and disease
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- Artist: Science Signaling
- Copyright: © 2017 American Association for the Advancement of Science
Podcasts:
Courtney Lane-Donovan and Joachim Herz discuss how a secreted protein that controls synaptic plasticity protects neurons from the toxic effects of amyloid β.
Kristopher Kahle explains how WNK1-dependent phosphorylation of an ion transporter ensures that immature neurons are stimulated, rather than inhibited, by the neurotransmitter GABA.
David Sweatt and John Halblitz explain how DNA methylation controls glutamatergic synaptic scaling, a type of synaptic plasticity important for learning and memory.
Guy Salvesen explains how arsenic trioxide treatment switches which SUMO variant is conjugated to an oncoprotein, thus triggering its degradation.
Min Zhao and Peter Devreotes discuss the results from a genetic screen to identify genes important for electrotaxis in the slime mold Dictyostelium discoideum.
Kathleen Maguire-Zeiss, Stefano Daniele, and Hang Yin explain why drugs that inhibit signaling by pattern recognition receptors on microglia reduce neuroinflammation associated with synucleinopathies such as Parksinson's disease.
James Martin explains how the transcriptional coactivator Yap promotes migration of cardiomyocytes to the site of injury during heart regeneration.
Gerald Dorn and Moshi Song discovered that two related isoforms of protein kinase C control growth of the heart in both developmental and pathological contexts.
Andrea Blanka and Susanne Häussler explain why altered fatty acid metabolism enhances the ability of a disease-associated strain of Pseudomonas aeruginosa to form biofilms.
Sarah Mense and Ramon Parsons explain how mutations in PREX2 overcome tumor suppression by PTEN.
Tilman Borggrefe describes how CARM1-mediated methylation promotes degradation of the Notch intracellular domain to enable transient Notch signaling during development.
Richard Neutze discusses a structural analysis of light-induced structural changes in the visual pigment rhodopsin.
Venuprasad Poojary explains how the ubiquitin ligase Itch prevents chronic skin inflammation.
Kunxin Luo describes the multiple mechanisms through which Ski inhibits activity of the transcriptional coactivator TAZ to suppress breast cancer metastasis.
Ben Major and Matt Walker discuss findings that suggest Wnt signaling inhibitors could be useful for treating a common type of lymphoma.