Science Signaling Podcast

Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms.

The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia.

Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling.

Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death.

Petra May discusses new findings about a role for LRP1 in inhibiting inflammation.

Ben Major and Randall Moon discuss their screen for cell type-specific modifiers of Wnt signaling.

Rune Linding explains how combining NetPhorest with a genetic screen enables researchers to gain insight into the relationships among the identified players..

The bacteria that cause gingivitis evade destruction by promoting crosstalk between two receptors that regulate the immune response.

Bacteria secrete factors that regulate genes that contribute to virulence.

Some anesthetics activate TRPA1 channels to trigger pain and nerve-mediated inflammation.

Inhibition of NF-kappaB activation in macrophages results in a proinflammatory outcome.

Microvesicles carrying an oncogenic form of the epidermal growth factor receptor provide a mechanism for lateral spread of the malignant phenotype.

Some glial cells can generate action potentials and are hypersensitive to ischemic injury.

Mutations in the IGF-1 receptor are associated with longer life span in humans.

Glucose may stimulate the formation of fat tissue in muscle.