Science Signaling Podcast
Summary: Periodic audiocasts from Science Signaling, the leading journal of regulatory biology and cell signaling in physiology and disease
Sheila Collins explains that natriuretic peptides protect mice from the metabolic consequences of a high-fat diet by acting on adipose tissue.
Indu Ambudkar explains why radiation therapy for head and neck cancers causes dry mouth.
Nicole De Nisco and Kim Orth explain that the type 3 secretion system 1 of Vibrio parahaemolyticus initially rewires host cell signaling networks to promote cell survival then later kills the host cell.
Jonathan Jaggar explains how trafficking of regulatory subunits fine-tunes the activity of BK channels in arterial myocytes to limit vasoconstriction.
Science Signaling Chief Scientific Editor Michael Yaffe highlights some of the ways that signaling research can contribute to the Cancer Moonshot.
Saumya Das explains how the protein DDiT4L protects the heart from pathological hypertrophy.
Antoine Karnoub explains how increased expression of PTX3 promotes the growth of basal-like breast cancer cells.
Johannes Hell and Manuel Navedo explain that modification of a particular serine residue affects the activity of the L-type calcium channel Cav1.2 in the brain and vasculature, but not in the heart.
Marc Daëron explains how recruitment of the lipid phosphatase SHIP1 enables trans-inhibition by Fc receptors.
Bridget Wilson explains that transient homotypic interactions between pre-B cell receptors promotes survival of acute lymphoblastic leukemia cells.
Hagit Eldar-Finkelman describes a peptide that inhibits the kinase GSK-3 through an unusual mechanism and improves symptoms in a mouse model of Alzheimer’s disease.
Brian Feldman explains how a secreted protease inhibits diet- and glucocorticoid-induced differentiation of adipocytes.
Eric Haura describes the identification of new targets for treating lung cancers driven by ALK fusion proteins.
Benjamin Cravatt, John Teijaro, and Megan Blewett describe how the immunosuppressive drug DMF affects proteins in human T cells.
Michael Nielsen describes the extent and importance of arginine methylation in the human proteome.