Science Signaling Podcast

Signaling from two growth factors converges on the cell cycle inhibitor p57 to regulate proliferation and limit oncogenesis.

The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization.

Activity of the kinase CK2 promotes the generation of intracellular zinc waves by stimulating the zinc channel ZIP7.

Signaling through PAS kinases bypasses the pro-growth requirement of Tor2 in yeast.

Exploiting crosstalk between signaling pathways may lead to more effective melanoma therapies.

Suppression of conventional T cells by regulatory T cells requires inhibition of calcium signaling downstream of the T cell receptor.

Activation of the calcium-sensing receptor promotes its trafficking to the cell surface and enhances signaling.

The vacuolar ATPase is required for amino acid-mediated activation of mTORC1.

An engineered peptide blocks inflammation by inhibiting signaling through a proinflammatory receptor.

A combination of functional and proteomics approaches identifies regulators of ERK signaling in Drosophila.

Phosphorylation of the transcription factor Mad determines whether it mediates Wingless or BMP signaling.

By working together, cells can overcome the loss of information as it flows through a signaling network.

Activation of the small GTPase Rho downstream of a chemokine receptor is required for metastasis of some breast cancer cells.

Arginine methylation of RAF determines the specificity of the biological response to growth factors that activate the same signaling cascade.

Activating integrin signaling may be an effective strategy for developing therapeutics to reduce leukocyte recruitment during inflammation.