Summary: In this episode, I discuss loperamide (Imodium) pharmacology, adverse effects, and drug interactions. <br> <br> <br> <br> Loperamide has opioid-type activity in the gut but has extremely low oral bioavailability. This allows it to be used for diarrhea but at lower doses won't cause systemic opioid-like effects. <br> <br> <br> <br> Loperamide abuse has been reported. Excessive dosages can increase the risk of cardiac arrest and other cardiovascular concerns. <br> <br> <br> <br> Medication causes of diarrhea should be ruled out prior to starting a medication like loperamide. I discuss numerous medications that can cause diarrhea in this podcast.
