Speaking of Science
Summary: Known for its synergistic approach to biomedical science, the Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH). With 1,100 Principal Investigators and more than 4,000 Postdoctoral Fellows conducting basic, translational, and clinical research, the IRP is the largest biomedical research institution on earth. Its mission is science in pursuit of fundamental knowledge about living systems and the application of that knowledge to extend healthy life and reduce illness and disability throughout the world. In the IRP's new podcast, Speaking of Science, you will meet many of the federal researchers working to change lives by advancing all aspects of biomedicine.
Dennis Drayna, Ph.D., is a human geneticist who has identified mutations in several genes that cause communications disorders, particularly stuttering. In this second half of our conversation, we also delve into his lab’s ground-breaking work on how genetic variation affects the sense of taste and preference for menthol in cigarettes. Dr. Drayna is a Senior Investigator at NIH's National Institute on Deafness and Other Communication Disorders (NIDCD). Learn more at https://irp.nih.gov/pi/dennis-drayna
Dennis Drayna, Ph.D., is a human geneticist who has identified mutations in several genes that cause communications disorders, particularly stuttering. With so much to cover, we divided his episode into two parts. Part 1 focuses on Dr. Drayna’s research into the genetics of stuttering, using family- and population-based genetic methods. Dr. Drayna is a Senior Investigator at NIH's National Institute on Deafness and Other Communication Disorders (NIDCD). Learn more at https://irp.nih.gov/pi/dennis-drayna
When people refer to the NIH as the “National Institutes of Hope,” Dr. Bill Gahl is often who comes to mind. As a medical geneticist, he focuses on inborn errors of metabolism, including cystinosis, Hermansky-Pudlak syndrome, alkaptonuria, and ciliopathies. Dr. Gahl led the creation of the NIH’s Undiagnosed Diseases Program to provide answers for people with mysterious conditions. Dr. Gahl is a Senior Investigator at NIH's National Human Genome Research Institute (NHGRI). https://irp.nih.gov/pi/willi
Pancreatic cancer kills more than 40,000 Americans each year. Dr. Christine Alewine is testing and refining two recombinant immunotoxins to treat the disease. Her target is a protein called mesothelin present on the surface of several types of tumor cells, including pancreatic, ovarian, and some lung cancers. Dr. Alewine is an NIH Lasker Clinical Research Scholar and Principal Investigator in the National Cancer Institute's (NCI) Center for Cancer Research (CCR). https://irp.nih.gov/pi/christine-alewine
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk. Dr. Nehal Mehta directs the largest ongoing cohort study to date in psoriasis. His research shows that local inflammation in different areas of the body has systemic consequences, and treating that local inflammation can help heal heart disease. Dr. Mehta is an NIH Lasker Clinical Research Scholar and IRP Principal Investigator at the National Heart, Lung, and Blood Institute (NHLBI). https://irp.nih.gov/pi/nehal-mehta
In 2019, we are bringing you conversations with world-leading researchers working at the NIH IRP on problems across the spectrum of biomedicine. You’ll find out why they do what they do and how their efforts help people with rare and common conditions, from cancers to heart disease, mental health to genetic anomalies. Please tune in and share with your friends, family, and colleagues – and if you do, we hope you enjoy it.