Neurology® Podcast

1. Featured Article: Baseline symptoms and basal forebrain volume predict future psychosis in early Parkinson disease 2. What’s Trending: Drug pricing This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the May 1, 2018, print issue of Neurology. In the first segment, Dr. Jeff Ratliff talks with Dr. Matthew Barrett about his paper on predictors of psychosis in Parkinson disease. For the “What’s Trending” segment, Dr. Ted Burns discusses drug pricing with journalist Ike Swetlitz. DISCLOSURES: Dr. Ratliff has received a speaker honorarium from Haverford College. Dr. Barrett has received research support from Axovant Sciences, Inc. (clinical trial site PI), Azevan Pharmaceuticals (clinical trial site PI), Merck Sharp & Dohme Corp. (Clinical trial site PI), Biogen (clinical trial site PI), Virginia Center of Alzheimer´s and Related Diseases Research Award Fund (PI), U.S. Department of Defense Neurotoxin Exposure Treatment Parkinson's Research Career Progress Award (PI), and NIH (clinical trial site PI).Dr. Burns is the deputy section editor of the Neurology® podcast; has served on scientific advisory boards for Argenx, UCB, and CSL Behring; has received travel funding/speaker honoraria from Argenx and Alexion; and has received support for consulting activities from UCB Pharma and CSL Behring. Mr. Swetlitz is a reporter for StatNews.

1. Featured Article: Baseline symptoms and basal forebrain volume predict future psychosis in early Parkinson disease 2. What’s Trending: Drug pricing This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the May 1, 2018, print issue of Neurology. In the first segment, Dr. Jeff Ratliff talks with Dr. Matthew Barrett about his paper on predictors of psychosis in Parkinson disease. For the “What’s Trending” segment, Dr. Ted Burns discusses drug pricing with journalist Ike Swetlitz. DISCLOSURES: Dr. Ratliff has received a speaker honorarium from Haverford College. Dr. Barrett has received research support from Axovant Sciences, Inc. (clinical trial site PI), Azevan Pharmaceuticals (clinical trial site PI), Merck Sharp & Dohme Corp. (Clinical trial site PI), Biogen (clinical trial site PI), Virginia Center of Alzheimer´s and Related Diseases Research Award Fund (PI), U.S. Department of Defense Neurotoxin Exposure Treatment Parkinson's Research Career Progress Award (PI), and NIH (clinical trial site PI).Dr. Burns is the deputy section editor of the Neurology® podcast; has served on scientific advisory boards for Argenx, UCB, and CSL Behring; has received travel funding/speaker honoraria from Argenx and Alexion; and has received support for consulting activities from UCB Pharma and CSL Behring. Mr. Swetlitz is a reporter for StatNews.

1. Featured Article: Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis 2. What’s Trending: Global, regional, and national burden of neurological disorders during 1990–2015 (from Lancet Neurology) This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 24, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Alexander Rae-Grant about the AAN Practice Guideline on disease-modifying therapies for adults with multiple sclerosis. For the “What’s Trending” segment, Dr. Jason Crowell interviews Dr. Theo Vos about findings from the Global Burden of Diseases, Injuries, and Risk Factors Study and the growing need for clinicians with neurologic expertise. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Rae-Grant has served on the Neurology Evidence Review Team, 2011-2018; receives publishing royalties from Handbook of Multiple Sclerosis (Springer Healthcare, 2010), Comprehensive review of clinical neurology, (Wolters Kluwer, 2012), 5 minute consult in neurology (Wolters Klower, 2012), Comprehensive review of clinical neurology second edition ( LWW, 2016), Ultimate review of neurology (DEMOS 2016), and Multiple Sclerosis and Related disorders (DEMOS, 2014); edits neurology chapters for Dynamic Medical, an online text book of medicine which is funded via library subscriptions; was involved in a clinical trial of biotin for multiple sclerosis with MedDay (no personal remuneration); and receives research support from NIH (grant #A6022304). Dr. Crowell reports no disclosures.

1. Featured Article: Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis 2. What’s Trending: Global, regional, and national burden of neurological disorders during 1990–2015 (from Lancet Neurology) This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 24, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Alexander Rae-Grant about the AAN Practice Guideline on disease-modifying therapies for adults with multiple sclerosis. For the “What’s Trending” segment, Dr. Jason Crowell interviews Dr. Theo Vos about findings from the Global Burden of Diseases, Injuries, and Risk Factors Study and the growing need for clinicians with neurologic expertise. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Rae-Grant has served on the Neurology Evidence Review Team, 2011-2018; receives publishing royalties from Handbook of Multiple Sclerosis (Springer Healthcare, 2010), Comprehensive review of clinical neurology, (Wolters Kluwer, 2012), 5 minute consult in neurology (Wolters Klower, 2012), Comprehensive review of clinical neurology second edition ( LWW, 2016), Ultimate review of neurology (DEMOS 2016), and Multiple Sclerosis and Related disorders (DEMOS, 2014); edits neurology chapters for Dynamic Medical, an online text book of medicine which is funded via library subscriptions; was involved in a clinical trial of biotin for multiple sclerosis with MedDay (no personal remuneration); and receives research support from NIH (grant #A6022304). Dr. Crowell reports no disclosures.

1. Featured Article: Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis 2. What’s Trending: Global, regional, and national burden of neurological disorders during 1990–2015 (from Lancet Neurology) This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 24, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Alexander Rae-Grant about the AAN Practice Guideline on disease-modifying therapies for adults with multiple sclerosis. For the “What’s Trending” segment, Dr. Jason Crowell interviews Dr. Theo Vos about findings from the Global Burden of Diseases, Injuries, and Risk Factors Study and the growing need for clinicians with neurologic expertise. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Rae-Grant has served on the Neurology Evidence Review Team, 2011-2018; receives publishing royalties from Handbook of Multiple Sclerosis (Springer Healthcare, 2010), Comprehensive review of clinical neurology, (Wolters Kluwer, 2012), 5 minute consult in neurology (Wolters Klower, 2012), Comprehensive review of clinical neurology second edition ( LWW, 2016), Ultimate review of neurology (DEMOS 2016), and Multiple Sclerosis and Related disorders (DEMOS, 2014); edits neurology chapters for Dynamic Medical, an online text book of medicine which is funded via library subscriptions; was involved in a clinical trial of biotin for multiple sclerosis with MedDay (no personal remuneration); and receives research support from NIH (grant #A6022304). Dr. Crowell reports no disclosures.

1. Featured Article: Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis 2. What’s Trending: Global, regional, and national burden of neurological disorders during 1990–2015 (from Lancet Neurology) This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 24, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy talks with Dr. Alexander Rae-Grant about the AAN Practice Guideline on disease-modifying therapies for adults with multiple sclerosis. For the “What’s Trending” segment, Dr. Jason Crowell interviews Dr. Theo Vos about findings from the Global Burden of Diseases, Injuries, and Risk Factors Study and the growing need for clinicians with neurologic expertise. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Rae-Grant has served on the Neurology Evidence Review Team, 2011-2018; receives publishing royalties from Handbook of Multiple Sclerosis (Springer Healthcare, 2010), Comprehensive review of clinical neurology, (Wolters Kluwer, 2012), 5 minute consult in neurology (Wolters Klower, 2012), Comprehensive review of clinical neurology second edition ( LWW, 2016), Ultimate review of neurology (DEMOS 2016), and Multiple Sclerosis and Related disorders (DEMOS, 2014); edits neurology chapters for Dynamic Medical, an online text book of medicine which is funded via library subscriptions; was involved in a clinical trial of biotin for multiple sclerosis with MedDay (no personal remuneration); and receives research support from NIH (grant #A6022304). Dr. Crowell reports no disclosures.

1. Featured Article: Clinical Reasoning: A young woman with symmetric weakness and behavioral disturbance 2. What’s Trending: DEFUSE 3 trial results on thrombectomy vs. standard therapy alone for ischemic stroke This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 17, 2018, print issue of Neurology. In the first segment, Dr. Dan Ackerman talks with Dr. Jon Rosenberg about the differential diagnosis of a young patient with symmetric weakness, behavioral changes, and bilateral infarcts. For the “What’s Trending” segment, Dr. Nicole Chiota speaks with Dr. Gregory Albers about findings from the DEFUSE 3 clinical trial. DISCLOSURES: Dr. Ackerman, Dr. Rosenberg, and Dr. Chiota-McCollum report no disclosures. Dr. Albers has served on a steering committee for Lundbeck and Covidien; serves on the editorial board for Stroke; holds a patent for RAPID software for MRI and CTP analysis of diffusion and perfusion data; has consulted for Astra Zeneca, Biogen, and iSchemaView; holds stock in iSchemaView; and has received research support from NINDS.

1. Featured Article: Clinical Reasoning: A young woman with symmetric weakness and behavioral disturbance 2. What’s Trending: DEFUSE 3 trial results on thrombectomy vs. standard therapy alone for ischemic stroke This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 17, 2018, print issue of Neurology. In the first segment, Dr. Dan Ackerman talks with Dr. Jon Rosenberg about the differential diagnosis of a young patient with symmetric weakness, behavioral changes, and bilateral infarcts. For the “What’s Trending” segment, Dr. Nicole Chiota speaks with Dr. Gregory Albers about findings from the DEFUSE 3 clinical trial. DISCLOSURES: Dr. Ackerman, Dr. Rosenberg, and Dr. Chiota-McCollum report no disclosures. Dr. Albers has served on a steering committee for Lundbeck and Covidien; serves on the editorial board for Stroke; holds a patent for RAPID software for MRI and CTP analysis of diffusion and perfusion data; has consulted for Astra Zeneca, Biogen, and iSchemaView; holds stock in iSchemaView; and has received research support from NINDS.

1. Featured Article: Clinical Reasoning: A young woman with symmetric weakness and behavioral disturbance 2. What’s Trending: DEFUSE 3 trial results on thrombectomy vs. standard therapy alone for ischemic stroke This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 17, 2018, print issue of Neurology. In the first segment, Dr. Dan Ackerman talks with Dr. Jon Rosenberg about the differential diagnosis of a young patient with symmetric weakness, behavioral changes, and bilateral infarcts. For the “What’s Trending” segment, Dr. Nicole Chiota speaks with Dr. Gregory Albers about findings from the DEFUSE 3 clinical trial. DISCLOSURES: Dr. Ackerman, Dr. Rosenberg, and Dr. Chiota-McCollum report no disclosures. Dr. Albers has served on a steering committee for Lundbeck and Covidien; serves on the editorial board for Stroke; holds a patent for RAPID software for MRI and CTP analysis of diffusion and perfusion data; has consulted for Astra Zeneca, Biogen, and iSchemaView; holds stock in iSchemaView; and has received research support from NINDS.

1. Featured Article: Clinical Reasoning: A young woman with symmetric weakness and behavioral disturbance 2. What’s Trending: DEFUSE 3 trial results on thrombectomy vs. standard therapy alone for ischemic stroke This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 17, 2018, print issue of Neurology. In the first segment, Dr. Dan Ackerman talks with Dr. Jon Rosenberg about the differential diagnosis of a young patient with symmetric weakness, behavioral changes, and bilateral infarcts. For the “What’s Trending” segment, Dr. Nicole Chiota speaks with Dr. Gregory Albers about findings from the DEFUSE 3 clinical trial. DISCLOSURES: Dr. Ackerman, Dr. Rosenberg, and Dr. Chiota-McCollum report no disclosures. Dr. Albers has served on a steering committee for Lundbeck and Covidien; serves on the editorial board for Stroke; holds a patent for RAPID software for MRI and CTP analysis of diffusion and perfusion data; has consulted for Astra Zeneca, Biogen, and iSchemaView; holds stock in iSchemaView; and has received research support from NINDS.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD 2. Neurology Today: Top research advances in 2017 This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD 2. Neurology Today: Top research advances in 2017 This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD 2. Neurology Today: Top research advances in 2017 This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD 2. Neurology Today: Top research advances in 2017 This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.

1. Featured Article: Rituximab before and during pregnancy: A systematic review, and a case series in MS and NMOSD 2. Neurology Today: Top research advances in 2017 This Neurology® Podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 10, 2018, print issue of Neurology. In the first segment, Dr. Stacey Clardy interviews Dr. Riley Bove about her paper on rituximab treatment before and during pregnancy in patients with multiple sclerosis and NMOSD. For the second segment, Dr. Andy Southerland speaks with Dr. Joseph Safdieh on the Neurology Today editorial selections for the top research advances in 2017. DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Southerland serves as Podcast Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Dr. Safdieh has served on scientific advisory board for Upsher Smith; receives publishing royalties from Rubin MP, Safdieh JE. Netters Concise Neuroanatomy (Elsevier 2007); and serves as Editor-in-Chief of Neurology Today.